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ChemicalBook >> CAS DataBase List >> Phenoxybenzamine hydrochloride

Phenoxybenzamine hydrochloride

Phenoxybenzamine hydrochloride  price.
  • $24.65 - $899
  • Product name: Phenoxybenzamine hydrochloride
  • CAS: 63-92-3
  • MF: C18H22ClNO.ClH
  • MW: 340.29
  • EINECS:200-569-7
  • MDL Number:MFCD00055152
  • Synonyms:benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)aminehydrochloride ;dibenzyran ;n-phenoxyisopropyl-n-benzyl-beta-chloroethylaminehydrochloride ;phenoxybenzamidehydrochloride ;BENZENE METHANAMINE HYDROCHLORIDE;DIBENZYLINE HYDROCHLORIDE;N-PHENOXYISOPROPYL-N-BENZYL-2-CHLOROETHYLAMINE HYDROCHLORIDE;PHENOXYBENZAMINE HYDROCHLORIDE
29 prices
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  • AHH
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Chem-Impex
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  • TCI Chemical
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Package
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  • 10mM(in 1mL DMSO)
  • ManufacturerAHH
  • Product numberAPI-1673
  • Product descriptionPhenoxybenzamine hydrochloride 98%
  • Packaging10g
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH533
  • Product descriptionPhenyoxybenzaminehydrochloride
  • Packaging250mg
  • Price$80
  • Updated2021-12-16
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  • ManufacturerAlfa Aesar
  • Product numberJ61900
  • Product descriptionPhenoxybenzamine hydrochloride
  • Packaging250mg
  • Price$24.65
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ61900
  • Product descriptionPhenoxybenzamine hydrochloride
  • Packaging1g
  • Price$43.65
  • Updated2024-03-01
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002313
  • Product descriptionDIBENZYLINE HYDROCHLORIDE 95.00%
  • Packaging1G
  • Price$153.3
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002313
  • Product descriptionDIBENZYLINE HYDROCHLORIDE 95.00%
  • Packaging2.5G
  • Price$796.77
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1343
  • Product descriptionPhenoxybenzamineHCl
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1343
  • Product descriptionPhenoxybenzamineHCl
  • Packaging200mg
  • Price$47
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1343
  • Product descriptionPhenoxybenzamineHCl
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1343
  • Product descriptionPhenoxybenzamineHCl
  • Packaging500mg
  • Price$86
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1343
  • Product descriptionPhenoxybenzamineHCl
  • Packaging1g
  • Price$145
  • Updated2021-12-16
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  • ManufacturerCayman Chemical
  • Product number16211
  • Product descriptionPhenoxybenzamine (hydrochloride) ≥98%
  • Packaging1g
  • Price$44
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number16211
  • Product descriptionPhenoxybenzamine (hydrochloride) ≥98%
  • Packaging5g
  • Price$193
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number16211
  • Product descriptionPhenoxybenzamine (hydrochloride) ≥98%
  • Packaging10g
  • Price$341
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number16211
  • Product descriptionPhenoxybenzamine (hydrochloride) ≥98%
  • Packaging25g
  • Price$426
  • Updated2024-03-01
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  • ManufacturerChem-Impex
  • Product number37770
  • Product descriptionPhenoxybenzaminehydrochloride,98%(Assaybytitration) 98%(Assaybytitration)
  • Packaging1G
  • Price$38.08
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1673 Phenoxybenzamine hydrochloride 98% 10g $500 2021-12-16 Buy
AK Scientific H533 Phenyoxybenzaminehydrochloride 250mg $80 2021-12-16 Buy
Alfa Aesar J61900 Phenoxybenzamine hydrochloride 250mg $24.65 2024-03-01 Buy
Alfa Aesar J61900 Phenoxybenzamine hydrochloride 1g $43.65 2024-03-01 Buy
American Custom Chemicals Corporation API0002313 DIBENZYLINE HYDROCHLORIDE 95.00% 1G $153.3 2021-12-16 Buy
American Custom Chemicals Corporation API0002313 DIBENZYLINE HYDROCHLORIDE 95.00% 2.5G $796.77 2021-12-16 Buy
ApexBio Technology B1343 PhenoxybenzamineHCl 1unit $28 2021-12-16 Buy
ApexBio Technology B1343 PhenoxybenzamineHCl 200mg $47 2021-12-16 Buy
ApexBio Technology B1343 PhenoxybenzamineHCl 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B1343 PhenoxybenzamineHCl 500mg $86 2021-12-16 Buy
ApexBio Technology B1343 PhenoxybenzamineHCl 1g $145 2021-12-16 Buy
Cayman Chemical 16211 Phenoxybenzamine (hydrochloride) ≥98% 1g $44 2024-03-01 Buy
Cayman Chemical 16211 Phenoxybenzamine (hydrochloride) ≥98% 5g $193 2024-03-01 Buy
Cayman Chemical 16211 Phenoxybenzamine (hydrochloride) ≥98% 10g $341 2024-03-01 Buy
Cayman Chemical 16211 Phenoxybenzamine (hydrochloride) ≥98% 25g $426 2024-03-01 Buy
Chem-Impex 37770 Phenoxybenzaminehydrochloride,98%(Assaybytitration) 98%(Assaybytitration) 1G $38.08 2021-12-16 Buy

Properties

Melting point :137.5°C
storage temp. :15-25°C
solubility :soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
form :powder
pka :pKa 4.4 (Uncertain)
color :white
Water Solubility :<0.01 g/100 mL at 18.5 ºC
Merck :14,7256
Stability :Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference :63-92-3(CAS DataBase Reference)
IARC :2B (Vol. 24, Sup 7) 1987
EPA Substance Registry System :N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride (63-92-3)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Phenoxybenzamine is a noncompetitive, irreversible α-adrenergic receptor antagonist (IC50 = 34.2 nM for α1; Kis = 0.06, 0.01, and 0.06 μM for α2A, α2B, and α2C, respectively) with antihypertensive activity. It forms a covalent bond with the adrenergic receptor, resulting in a slow onset and highly prolonged duration (2-8 days) of the blockade that subsides upon the synthesis of new adrenergic receptors. Due to its ability to selectively block longitudinal but not circular muscle contraction in human vas deferens, phenoxybenzamine has been explored as a form of male contraception to prevent sperm emission. The ability of phenoxybenzamine to block sympathetic signal transduction has also been explored in the context of complex regional pain syndrome.

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