849217-68-1 Basic information More..
Product Name:Cabozantinib
Synonyms:Cabozantinib(XL184Malate);Cabozantinib (XL184, BMS-907351);XL-186;1,1-cyclopropanedicarboxamide, n'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4-fluorophenyl)-;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide Cabozantinib (XL184, BMS-907351);Cabozantinib, >=98%;1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Cabozantinib
CAS:849217-68-1
MF:C28H24FN3O5
MW:501.51
EINECS:692-846-8
Mol File:849217-68-1.mol
849217-68-1

Use

In clinical trials, common adverse effects caused by cabozantinib include diarrhea, stomatitis, palmar-plantarrythrodysesthesia syndrome (PPES), and loss of weight, loss of appetite, nausea, fatigue, oral pain, taste disorders, high blood pressure, abdominal pain and constipation. The most common laboratory abnormalities ( 25%) were increased aspartate aminotransferase, alanine aminotransferase, lymphopenia, increased alkaline phosphatase level, hypocalcemia, neutropenia, thrombocytopenia, hypophosphatemia and hyperbilirubinemia. For patients receiving cabozantinib, 57% of patients have gotten increased level of thyroid stimulating hormone after initial dose, compared with patients receiving placebo, increased by 19%. Information regarding to the anticancer drug, mechanism of action, pharmacokinetics, side effects, and drug interactions of cabozantinib were compiled and edited by Yan Shi from Chemicalbook. (2015-10-23)

Cabozantinib manufacturers

  • Cabozantinib
  • US $0.00 / g
  • 2024-03-12
  • CAS:849217-68-1
  • Min. Order: 1g
  • Purity: 98% HPLC
  • Supply Ability: 1kg
  • Cabozantinib
  • US $0.00-0.00 / kg
  • 2023-12-26
  • CAS:849217-68-1
  • Min. Order: 1kg
  • Purity: 99%, Single impurity<0.1
  • Supply Ability: 1 ton
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