CS-1211
| 中文名称 | CS-1211 |
|---|---|
| 中文同义词 | RAR激动剂(AGN194310);化合物 T14143 |
| 英文名称 | AGN 194310 |
| 英文同义词 | AGN 194310;AGN-194310, 194310;CS-1211;AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310;VTP 194310;VTP194310;VTP-194310;AGN |
| CAS号 | 229961-45-9 |
| 分子式 | C28H24O2S |
| 分子量 | 424.55 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 229961-45-9.mol |
| 结构式 |  |
CS-1211 性质
| 沸点 | 598.1±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | >16.8mg/mL，溶于 DMSO |
| 形态 | 粉末 |
| 酸度系数(pKa) | 4.02±0.10(Predicted) |
|
RARα 3 nM (Kd) |
RARβ 2 nM (Kd) |
RARγ 5 nM (Kd) |
AGN194310 potently inhibits colony formation by all three lines, with IC50 values of 16 nM for LNCaP cells; 18 nM for PC3 cells; and 34 nM for DU-145 cells.
AGN 194310 (50 nM, 100 nM; LNCaP, PC-3 and DU-145 cells) inhibits colony formation at concentrations of 50 nM and 100 nM alone and in combination with TTNPB.
AGN 194310 (1 μM; 72 hours; LNCaP cells) treatment results in 80% apoptosis.
Cell Viability Assay
| Cell Line: | LNCaP, PC-3 and DU-145 cells. |
| Concentration: | 50 nM, 100 nM |
| Incubation Time: | |
| Result: | When used together with 100 nM TTNPB, there was almost complete reversal of the growth inhibitory effect of 50 nM and partial reversal of the effect of 100 nM. |
Apoptosis Analysis
| Cell Line: | LNCaP cells |
| Concentration: | 1 μM |
| Incubation Time: | 72 hours |
| Result: | Induced apoptosis in LNCaP cells. |
AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte-progenitor cells is observed in the bone marrow of mice after treatment with AGN194310.
| Animal Model: | Female C57Bl/6J mice (Five-week-old (34-37 days)) |
| Dosage: | 0.5 mg/kg/day |
| Administration: | Oral gavage; every day; for 10 days |
| Result: | The number of granulocytes was significantly increased across haemopoietic compartments. Progenitor cells containing granulocytes also increased significantly. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-16681 | CS-1211 AGN 194310 | 229961-45-9 | 1mg | 1500元 |
| 2024/01/25 | HY-16681 | CS-1211 AGN 194310 | 229961-45-9 | 5mg | 5500元 |