大戟二烯醇
| 中文名称 | 大戟二烯醇 |
|---|---|
| 中文同义词 | 大戟二烯醇;大戟二烯醇对照品;大戟甾醇;大戟醇二烯醇 |
| 英文名称 | euphol |
| 英文同义词 | Lanosta-8,24-dien-3-ol,(3b,13a,14b,17a)-;euphol;Euphol, Euphadienol;alpha-Eupho;(13α,14β,17α)-5α-Lanosta-8,24-dien-3β-ol;Euphadienol;(3S,5R,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol;Lanosta-8,24-dien-3-ol, (3β,13α,14β,17α)- |
| CAS号 | 514-47-6 |
| 分子式 | C30H50O |
| 分子量 | 426.72 |
| EINECS号 | |
| 相关类别 | 中药对照品;标准品;植物提取物;对照品;对照品-中药对照品;标准品 -中药标准品;三萜;标准品，对照品 |
| Mol文件 | 514-47-6.mol |
| 结构式 |  |
大戟二烯醇 性质
| 熔点 | 116-117℃ |
|---|---|
| 沸点 | 498.9±44.0 °C(Predicted) |
| 密度 | 0.98±0.1 g/cm3 (20 ºC 760 Torr) |
| 储存条件 | -20°C, protect from light |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 15.16±0.70(Predicted) |
Euphol 是一种四环三萜醇，是从 Euphorbia tirucalli 的汁液中分离出来的，具有抗炎和免疫调节作用，具有口服活性。 Euphol 通过一种可逆机制抑制单酰基甘油脂肪酶 (MGL) 的活性，IC50=315 nM。 外周 MGL 抑制可调节内源性大麻素系统从而阻止炎症性疼痛的发展。
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Human Endogenous Metabolite
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Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC 50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively. Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins.
Cell Proliferation Assay
| Cell Line: | T47D cells |
| Concentration: | 0.01, 0.03, 0.1 and 0.3 mM |
| Incubation Time: | 24, 48 and 72 hours |
| Result: | Decreased the percentage of viable cells. |
Western Blot Analysis
| Cell Line: | T47D cells |
| Concentration: | 0.03 mM |
| Incubation Time: | 48 and 72 hours |
| Result: | Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D. |
化学性质
白色粉末，易溶于正己烷、三氯甲烷、甲醇，来源于甘遂，京大戟。用途
大戟二烯醇具有抗高血压的作用。