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NPS 2143

NPS 2143 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:NPS2143
CAS:284035-33-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:nps 2143
CAS:284035-33-2
Purity:99% Package:1kg
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:NPS 2143
CAS:284035-33-2
Purity:>=99% Package:1.8KG;9.8USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:NPS-2143;SB 262470A;NPS 2143;SB262470
CAS:284035-33-2
Purity:99.0% Package:1 mL * 10mM (in DMSO);10 mg;25 mg;5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:NPS 2143
CAS:284035-33-2
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

NPS 2143 manufacturers

  • NPS 2143
  • NPS 2143 pictures
  • $9.80 / 1.79999995231628KG
  • 2019-12-26
  • CAS:284035-33-2
  • Min. Order: 1g
  • Purity: ≥99%
  • Supply Ability: 100kg
NPS 2143 Basic information
Product Name:NPS 2143
Synonyms:2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2143);2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile;NPS 2143 hydrochloride;Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-;NPS 2143;SB-262470(NPS-2143);1-diMethyl-2-(2-naphthalenyl)ethyl]aMino]-2-hydroxypropoxy]-;2-chloro-6-[(2R)-3-[[1
CAS:284035-33-2
MF:C24H25ClN2O2
MW:408.92
EINECS:
Product Categories:API intermediates
Mol File:284035-33-2.mol
NPS 2143 Structure
NPS 2143 Chemical Properties
Boiling point 608.4±55.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
storage temp. Desiccate at RT
solubility ≥40.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH
form Powder
pka13.67±0.20(Predicted)
Safety Information
MSDS Information
NPS 2143 Usage And Synthesis
UsesNPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.
Biological Activitynps-2143 is a novel and selective antagonist of casr (ca2+-sensing receptor) with the ec50 value of 4.27mm for [ca2+]o [1].calcilytics nps-2143 has been reported to diminish the sensitivity of the casr for [ca2+]o, resulting in an attenuated signal transduction in vitro and increased secretion of pth in vivo. in addition, the ec50 values of nps-2143 are 4.27, 1.56, 1.61, 2.46, 2.07 and 3.15mm for the wild-type casr, mutant casr (t151r, p221l, e767q, g830s, and a844t), respectively. apart from these, in hek 293t cells expressing casr, nps-2143 has been revealed to inhibit the [ca2+]o-induced cytosolic calcium signal in a concentration-dependent manner [1]..
targetCa(2+) receptor
references[1] letz s1, rus r, haag c, dörr hg, schnabel d, möhlig m, schulze e, frank-raue k, raue f, mayr b, schöfl c. novel activating mutations of the calcium-sensing receptor: the calcilytic nps-2143 mitigates excessive signal transduction of mutant receptors. j clin endocrinol metab. 2010 oct;95(10):e229-33.
NPS 2143 Preparation Products And Raw materials
Tag:NPS 2143(284035-33-2) Related Product Information
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