4'-叔-丁基二甲基硅烷基-6-羟基雷洛昔芬
| 中文名称 | 4'-叔-丁基二甲基硅烷基-6-羟基雷洛昔芬 |
|---|---|
| 中文同义词 | 4'-叔-丁基二甲基硅烷基-6-羟基雷洛昔芬;4'-特丁基二甲基硅烷基-6-羟基雷洛昔芬 |
| 英文名称 | 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene |
| 英文同义词 | [2-[4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]Methanone;6-Hydroxy-4'-tert-butyldiMethylsylyl Raloxifene;4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene;4a€-tert-Butyldimethylsilyl-6-hydroxy Raloxifene;Methanone, [2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-;Sulfamic Acid Impurity 6 |
| CAS号 | 174264-46-1 |
| 分子式 | C34H41NO4SSi |
| 分子量 | 587.84414 |
| EINECS号 | |
| 相关类别 | Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 174264-46-1.mol |
| 结构式 |  |
4'-叔-丁基二甲基硅烷基-6-羟基雷洛昔芬 性质
| 储存条件 | Refrigerator |
|---|---|
| 溶解度 | 可溶于丙酮、氯仿、二氯甲烷、乙醇、甲醇 |
| 形态 | 固体 |
| 颜色 | 粘黄色 |
| CAS 数据库 | 174264-46-1 |
4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) 是一种Raloxifene 与叔丁基二甲基甲硅烷基氯的反应产物。4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 可用于合成 Raloxifene 6-glucuronide。
The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide.