MYRIOCIN

MYRIOCIN Suppliers list
Company Name: Dalian Meilun Biotech Co., Ltd.  Gold
Tel: 0411-66771943;0411-66771942
Email: sales@meilune.com
Products Intro: Product Name:Myriocin from Mycelia sterilia
CAS:35891-70-4
Purity:98% Package:820RMB/5MG Remarks:MB1829
Company Name: J & K SCIENTIFIC LTD.  
Tel: 400-666-7788 +86-10-82848833
Email: jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro: Product Name:Myriocin, 99%, from Mycelia sterilia
CAS:35891-70-4
Purity:99% Package:5MG
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:Myriocin;(2S,3R,4R,6E)-2-AMino-3,4-dihydroxy-2-(hydroxyMethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-AMino-3,4-dihydroxy-2-(hydroxyMethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; TherMozyMocidin; (2S,3R,4R)-(E)-2-AMino-3,4-dihydroxy-2-hydroxyMethyl-14-oxoeicos-6-enoic Acid
CAS:35891-70-4
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
Company Name: Syntechem Co.,Ltd  
Tel: Please Email
Email: info@syntechem.com
Products Intro: Product Name:(2S,3R,4R,E)-2-aMino-3,4-dihydroxy-2-(hydroxyMethyl)-14-oxoicos-6-enoic acid
CAS:35891-70-4
Purity:97% Package:1g;5g;25g;100g;250g;1kg;5kg;10kg;25kg Remarks:we offer low price custom synthesis and contract manufacturing
Company Name: BOC Sciences  
Tel:
Email: info@bocsci.com
Products Intro: Product Name:Myriocin
CAS:35891-70-4
MYRIOCIN Basic information
Product Name:MYRIOCIN
Synonyms:MYRIOCIN;MYRIOCIN, MYCELIA STERILIA;THERMOZYMOCIDIN;2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid;Myriocin, 99%, from Mycelia sterilia;6e))-4s*;6-eicosenoicacid,2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-,(2s-(2r*,3s;[2S,3R,4R,6E]-2-AMINO-3,4-DIHYDROXY-2-[HYDROXYMETHYL]-14-OXO-6-EICOSENOIC ACID
CAS:35891-70-4
MF:C21H39NO6
MW:401.54
EINECS:636-862-5
Product Categories:antibiotic
Mol File:35891-70-4.mol
MYRIOCIN Structure
MYRIOCIN Chemical Properties
Melting point 170-172℃
storage temp. 2-8°C
solubility methanol: 2 mg/mL
form powder
color off-white
InChIKeyZZIKIHCNFWXKDY-XFXZXTDPSA-N
Safety Information
Hazard Codes Xi,Xn
Risk Statements 22
Safety Statements 24/25
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS JX3890000
HS Code 29225090
MSDS Information
ProviderLanguage
SigmaAldrich English
MYRIOCIN Usage And Synthesis
Chemical PropertiesWhite powder
UsesMyriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin i s a useful biochemical research tool for depleting cells of sphingolipids.
UsesMyriocin is an α-amino fatty acid derived from several genera of fungi, notably Myriococcum, Melanconis and Isaria. Myriocin potently inhibits sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depleting cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant.
DefinitionChEBI: An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.
UsesMyriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model.[Cayman Chemical]
MYRIOCIN Preparation Products And Raw materials
Tag:MYRIOCIN(35891-70-4) Related Product Information
Metronidazole Ceramides dl-3-hydroxynorvaline MYRIOCIN 2-Methyl-L-serine 2-AMINO-3-HYDROXY-2-METHYLBUTANOIC ACID L(+)-allo-Threonine 2-Methyl-D-serine METHYL 6-TRANS-OCTADECENOATE (2S,3S)-2-AMINO-3-HYDROXY-PENTANOIC ACID (2S,3S)-3-HYDROXY-L-ISOVALINE (D,L)-2-AMINO-HEPT-6-ENOIC ACID