磷酸哌喹
| 中文名称 | 磷酸哌喹 |
|---|---|
| 中文同义词 | 磷酸哌喹;1,3-双[4-(7-氯-喹啉-4-基)哌嗪-1-基]丙烷磷酸盐;磷酸喹哌;哌喹磷酸盐 |
| 英文名称 | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate |
| 英文同义词 | 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate;PIPERAQUINE PHOSPHATE;Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline);antimalarial drugs PIPERAQUINE PHOSPHATE;2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP;Piperaquine PhosphateQ: What is Piperaquine Phosphate Q: What is the CAS Number of Piperaquine Phosphate Q: What is the storage condition of Piperaquine Phosphate Q: What are the applications of Piperaquine Phosphate |
| CAS号 | 85547-56-4 |
| 分子式 | C29H32Cl2N6.H3PO4 |
| 分子量 | 633.51 |
| EINECS号 | 1312995-182-4 |
| 相关类别 | 原料药;医药中间体;原料;医药原料;科研试剂;医用原料;化学试剂 |
| Mol文件 | 85547-56-4.mol |
| 结构式 |  |
磷酸哌喹 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：不溶； |
| 水溶解性 | Water: 2 mg/mL (3.16 mM) |
Piperaquine phosphate 是一种双喹啉抗疟药，可以与青蒿素联用于抗疟研究。
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.
Piperaquine (90 mg/kg; a single i.p.) exhibits the t
1/2
, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.
| Animal Model: | Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites |
| Dosage: | 0, 10, 30, 90 mg/kg |
| Administration: | A single i.p. administration |
| Result: |
The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg. |
| Animal Model: | Male Swiss mice (6 weeks old) |
| Dosage: | 90 mg/kg (Pharmacokinetic Analysis) |
| Administration: | A single i.p. administration |
| Result: | t 1/2 =17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |