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| | 4-(Hydroxyamino)-4-oxobutanoic acid Basic information |
| Product Name: | 4-(Hydroxyamino)-4-oxobutanoic acid | | Synonyms: | 3-(Hydroxyaminocarbonyl)propionic acid;4-(Hydroxyamino)-4-oxobutanoic acid;N-Hydroxysuccinamidic acid;Butanoic acid, 4-(hydroxyamino)-4-oxo-;Tofacitinib Impurity 208 | | CAS: | 4743-99-1 | | MF: | C4H7NO4 | | MW: | 133.1 | | EINECS: | | | Product Categories: | | | Mol File: | 4743-99-1.mol |  |
| | 4-(Hydroxyamino)-4-oxobutanoic acid Chemical Properties |
| Melting point | 82-86 °C(Solv: acetonitrile (75-05-8)) | | density | 1.436±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | pka | 5.28±0.10(Predicted) |
| | 4-(Hydroxyamino)-4-oxobutanoic acid Usage And Synthesis |
| Preparation | To a refluxing solution of 5.0 gm (0.05 mole) of succinic anhydride in 100 ml of benzene is added a solution of 6.3 gm (0.05 mole) of O-ben- zylhydroxylamine in 20 ml of benzene. As soon as the addition has been completed, the reaction mixture is cooled, and the precipitated product is separated. Upon recrystallization from a benzene-methyl ethyl ketone mixture, 7.6 gm (68.2%) of N-benzyloxysuccinamic acid, m.p. 95-96°C isolated.
A suspension of 4.3 gm (0.0193 mole) of this intermediate and a stron- tium carbonate catalyst containing 5% palladium in methyl ethyl ketone is hydrogenated. Upon working up the reaction mixture, 1.45 gm (56.7%) of succinomonohydroxamic acid, m.p. 95-96°C is isolated.
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| | 4-(Hydroxyamino)-4-oxobutanoic acid Preparation Products And Raw materials |
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