4-(Hydroxyamino)-4-oxobutanoic acid

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CAS:4743-99-1
Purity:0.98 Package:1KG;5KG;25KG
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Products Intro: Product Name:4-(Hydroxyamino)-4-oxobutanoic acid
CAS:4743-99-1
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CAS:4743-99-1
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Products Intro: Product Name:4-(hydroxyamino)-4-oxobutanoic acid
CAS:4743-99-1
Package:10 g/;100 g/
4-(Hydroxyamino)-4-oxobutanoic acid Basic information
Product Name:4-(Hydroxyamino)-4-oxobutanoic acid
Synonyms:3-(Hydroxyaminocarbonyl)propionic acid;4-(Hydroxyamino)-4-oxobutanoic acid;N-Hydroxysuccinamidic acid;Butanoic acid, 4-(hydroxyamino)-4-oxo-;Tofacitinib Impurity 208
CAS:4743-99-1
MF:C4H7NO4
MW:133.1
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Mol File:4743-99-1.mol
4-(Hydroxyamino)-4-oxobutanoic acid Structure
4-(Hydroxyamino)-4-oxobutanoic acid Chemical Properties
Melting point 82-86 °C(Solv: acetonitrile (75-05-8))
density 1.436±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
pka5.28±0.10(Predicted)
CAS DataBase Reference4743-99-1
Safety Information
MSDS Information
4-(Hydroxyamino)-4-oxobutanoic acid Usage And Synthesis
PreparationTo a refluxing solution of 5.0 gm (0.05 mole) of succinic anhydride in 100 ml of benzene is added a solution of 6.3 gm (0.05 mole) of O-ben- zylhydroxylamine in 20 ml of benzene. As soon as the addition has been completed, the reaction mixture is cooled, and the precipitated product is separated. Upon recrystallization from a benzene-methyl ethyl ketone mixture, 7.6 gm (68.2%) of N-benzyloxysuccinamic acid, m.p. 95-96°C isolated.
A suspension of 4.3 gm (0.0193 mole) of this intermediate and a stron- tium carbonate catalyst containing 5% palladium in methyl ethyl ketone is hydrogenated. Upon working up the reaction mixture, 1.45 gm (56.7%) of succinomonohydroxamic acid, m.p. 95-96°C is isolated.
Preparation of N-Hydroxysuccinamic Acid
4-(Hydroxyamino)-4-oxobutanoic acid Preparation Products And Raw materials
Tag:4-(Hydroxyamino)-4-oxobutanoic acid(4743-99-1) Related Product Information
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