PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
| 中文名称 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- |
|---|---|
| 中文同义词 | 化合物RO 67-7476 |
| 英文名称 | Ro 67-7476 |
| 英文同义词 | Ro 67-7476;Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-;(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine;RO67-7476;RO-67-7476;excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor |
| CAS号 | 298690-60-5 |
| 分子式 | C17H18FNO2S |
| 分子量 | 319.39 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 298690-60-5.mol |
| 结构式 | ![PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- 结构式](CAS/20181012/GIF/298690-60-5.gif) |
PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- 性质
| 沸点 | 452.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.268±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | DMSO：30.0（最大浓度 mg/mL）；93.9（最大浓度 mM） |
| 酸度系数(pKa) | -5.53±0.40(Predicted) |
| 形态 | 粉末 |
|
mGluR1a 60.1 nM (EC 50 ) |
In the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5. Ro 67-7476 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC 50 =163.3 nM). The EC50 value of full P-ERK1/2 activation for Ro 67-7476 are nearly identical to the EC 50 for calcium mobilization potentiation.Ro 67-7476 increases basal cAMP production approximately by 8%. It potentiated threshold responses to glutamate in the cAMP accumulation assay, with an EC 50 value of 17.7 µM.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100403 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- Ro 67-7476 | 298690-60-5 | 2mg | 500元 |
| 2024/01/25 | HY-100403 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- Ro 67-7476 | 298690-60-5 | 10mM * 1mLin DMSO | 878元 |