苯赖加压素乙酸酯
| 中文名称 | 苯赖加压素乙酸酯 |
|---|---|
| 中文同义词 | 苯赖加压素乙酸酯;N-[5-氨基-1-(氨基甲酰基甲基氨基甲酰基)戊基]-1-[19-氨基-13,16-二苄基-10-(2-氨基甲酰基乙基)-7-(氨基甲酰基甲基)-6,9,12,15,18-五氧代-1,2-二硫-5,8,11,14,17-五氮杂环二十烷-4-羰基]吡咯烷-2-羧酰胺乙酸盐;催产素杂质 12;苯赖加压素乙酸盐 |
| 英文名称 | Felypressin Acetate |
| 英文同义词 | Oxytocin Impurity 12 |
| CAS号 | 914453-97-7 |
| 分子式 | C48H69N13O13S2 |
| 分子量 | 1100.28 |
| EINECS号 | |
| 相关类别 | Amino Acids & Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 914453-97-7.mol |
| 结构式 |  |
苯赖加压素乙酸酯 性质
| 储存条件 | Store at -20°C |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Water : 100 mg/mL (Need ultrasonic) |
| 序列 | Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6) |
Vasopressin 1
Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells.
Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure.
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors.