TC-MCH 7C
| 中文名称 | TC-MCH 7C |
|---|---|
| 中文同义词 | 化合物 T13101;TC-MCH 7C,黑色素浓缩激素受体1(MCH1R)拮抗剂 |
| 英文名称 | TC-MCH 7c |
| 英文同义词 | TC-MCH 7c;4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone;4-(4-Fluoro-benzyloxy)-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-pyridin-2-one;TCMCH 7c,TC MCH 7c;2(1H)-Pyridinone, 4-[(4-fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]- |
| CAS号 | 864756-35-4 |
| 分子式 | C24H25FN2O3 |
| 分子量 | 408.47 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 864756-35-4.mol |
| 结构式 |  |
TC-MCH 7C 性质
| 熔点 | 124-126 °C |
|---|---|
| 沸点 | 606.3±55.0 °C(Predicted) |
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | 1eq 中可溶解至 100 mM。 HCl 和 50 mM DMSO 溶液 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 9.60±0.20(Predicted) |
TC-MCH 7c 是一种苯基吡啶酮衍生物，一种口服有效的，选择性的且可穿透血脑屏障的 MCH1R 拮抗剂，对 hMCH1R 的 IC50 为 5.6 nM。TC-MCH 7c 对人和小鼠 MCH1R 的 Ki 分别为 3.4 nM 和 3.0 nM。
IC50: 5.6 nM (hMCH
1
R)
Ki: 3.4 nM (hMCH
1
R) and 3.0 nM (mouse MCH
1
R)
TC-MCH 7c has an IC
50
of 9.7 μM for MCH
1
R in [Ca
2+
]i mobilization.
TC-MCH 7c has IC
50
s of 23 nM and 9.0 μM for FLIPR and hERG, respectively.
TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) exhibits excellent body weight reduction in a dose-dependent manner in DIO mice model.
TC-MCH 7c (oral; 3-30 mg/kg) with 30 mg/kg has plasma concentrations of 5.1, 1.8, and 0.7 μM at 2, 15, and 24 hours, respectively.
| Animal Model: | C57BL/6J DIO mice |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | Oral; once-daily for 1.5 months |
| Result: | Exhibited excellent body weight reduction in a dose-dependent manner. |
| Animal Model: | Diet-induced obesity mice |
| Dosage: | 3, 10 and 30 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Oral |
| Result: | Plasma concentrations at 2, 15, and 24 hours were 5.1, 1.8, and 0.7 μM, respectively. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-107623 | TC-MCH 7C TC-MCH 7c | 864756-35-4 | 1mg | 1950元 |
| 2024/04/30 | HY-107623 | TC-MCH 7C TC-MCH 7c | 864756-35-4 | 5mg | 5850元 |