HAMNO

HAMNO 更多供应商
公司名称: BOC Sciences  
联系电话: 16314854226
产品介绍: 英文名称:HAMNO
CAS:138736-73-9
纯度:99% 备注:HAMNO is a novel protein interaction inhibitor of replication protein A (RPA), which is involved in the ATR/Chk1 pathway. HAMNO acts by binding to the N-terminal DBD-F domain of RPA70. HAMNO inhibits
公司名称: 上海陶术生物科技有限公司  
联系电话: 15002134094 021-33632979
产品介绍: 中文名称:化合物HAMNO
英文名称:HAMNO
CAS:138736-73-9
纯度:90%-99% 包装信息:10 mg;100 mg;50 mg;5 mg;25 mg;1 mL * 10 mM (in DMSO); 备注:试剂级,仅用于科研使用
公司名称: 上海楼岚生物科技有限公司  
联系电话: 15000506266 021-52996696
产品介绍: 英文名称:NSC111847
CAS:138736-73-9
纯度:98% HPLC 包装信息:5mg,10mg,50mg,100mg,1g,5g
公司名称: 上海一飞生物科技有限公司  
联系电话: 021-65675885
产品介绍: 英文名称:HAMNO
CAS:138736-73-9
纯度:99% 包装信息:5mg;10mg;25mg;50mg 备注:试剂级
公司名称: 上海瀚香生物科技有限公司  
联系电话: 17754423994 177-54423994
产品介绍: 英文名称:HAMNO
CAS:138736-73-9
纯度:98% HPLC LCMS 包装信息:100mg;500mg;1g;5g;10g
HAMNO
生物活性靶点体外研究体内研究 MSDS 用途与合成方法 HAMNO价格(试剂级) 上下游产品信息
中文名称:HAMNO
中文同义词:化合物HAMNO
英文名称:HAMNO
英文同义词:HAMNO;NSC111847;NSC111847,HAMNO;HAMNO (NSC111847);CID 6335338;HAMNO; CID 6335338; MLS000737724; NSC111847; NSC-111847; NSC111847;MLS000737724;2(1H)-Naphthalenone, 1-[[(2-hydroxyphenyl)amino]methylene]-
CAS号:138736-73-9
分子式:C17H13NO2
分子量:263.29
EINECS号:604-604-1
相关类别:
Mol文件:138736-73-9.mol
HAMNO
HAMNO 性质
沸点 488.8±45.0 °C(Predicted)
密度 1.392±0.06 g/cm3(Predicted)
酸度系数(pKa)9.98±0.35(Predicted)
HAMNO 用途与合成方法
生物活性HAMNO (NSC-111847) 是一种有效的、选择性的、具有抗肿瘤活性的 replication protein A (RPA) 的抑制剂。HAMNO 可抑制 ATR 的自磷酸化及ATR诱导的RPA32 Ser33磷酸化。
靶点
TargetValue
RPA
()
ATR
()
体外研究

HAMNO is a novel protein interaction inhibitor of replication protein A (RPA). RPA is involved in the ATR/Chk1 pathway. HAMNO alone inhibits colony formation in both HNSCC cell lines in the low micromolar range. HAMNO combined with etoposide significantly inhibits colony formation to a greater degree than HAMNO alone. After UMSCC38 cells are exposed to HAMNO, increased pan-nuclear γ-H2AX staining occurs in a dose dependent manner. Cancer derived UMSCC38 cells, as well as another cancer cell line, UMSCC11B, have prominent γ-H2AX staining, particularly after incubation with 20 μM HAMNO. Both UMSCC38 and OKF4 cells present increased γ-H2AX staining after addition of HAMNO, with the greatest increase in signal occurring in S-phase.

体内研究

In mice, HAMNO slows the progression of UMSCC11B tumors. Ser33 of RPA32, an ATR substrate, is highly phosphorylated after two hours of treatment with 20 μM of etoposide, which is reduced with the addition of 2 μM HAMNO, and is nearly absent at higher concentrations, demonstrating an in vivo effect of HAMNO as an inhibitor of RPA32 phosphorylation by ATR.

安全信息
HAMNO 价格(试剂级)
更新日期产品编号产品名称CAS编号包装价格
2021/06/02S0148HAMNO138736-73-95mg670.46元
2021/06/02S0148HAMNO138736-73-925mg2066.47元
"HAMNO" 相关产品信息()
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