N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸
中文名称 | N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸 |
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中文同义词 | N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸;芴甲氧羰基-苏氨酸(半乳糖胺(AC)3-Α-D)基;FMOC-THR[GALNAC(AC)3-伪-D]-OH;N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-Α-D-吡喃半乳糖基)-L-苏氨酸;N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸;N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-Α-D-吡喃半乳糖基)-L-苏氨酸,GALNAC L-THREONINE;半乳糖胺L-苏氨酸;N-芴甲氧羰基-O-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-Α-D-吡喃半乳糖基)-L-苏氨酸 |
英文名称 | FMOC-THR(GALNAC(AC)3-ALPHA-D)-OH |
英文同义词 | N-FMOC-O-(3,4,6,-TRI-O-ACETYL-2-ACETAMIDO-2-DEOXY-Α-D-GALACTOPYRANOSYL)-L-THREONINE;Fmoc-L-Ser(α-D-GalNAc(Ac)3)-OH;Fmoc-L-Thr(GalNAc(Ac)3-α-D)-OH;Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine≥ 97% (HPLC);Fmoc-Thr(AcAcNH-α-Gal)-OH Novabiochem;N-FMOC-O-(2-ACETAMIDO-3,4,6-TRI-O-ACETYL-2-DEOXY-ALPHA-D-GALACTOPYRANOSYL)-L-THREONINE;Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine;Fmoc-L-Thr(α-D-GalNAc(Ac)3)-OH |
CAS号 | 116783-35-8 |
分子式 | C33H38N2O13 |
分子量 | 670.66 |
EINECS号 | |
相关类别 | 糖基氨基酸;糖基化氨基酸;生化试剂;糖氨基酸和糖肽;基准试剂;Glycoamino Acid;Amino Acid;Carbohydrates & Derivatives;Fluorescent Labels & Indicators;Inhibitors;Protein Kinase Inhibitors and Activators |
Mol文件 | 116783-35-8.mol |
结构式 |
N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸 性质
熔点 | 178-183°C |
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沸点 | 857.1±65.0 °C(Predicted) |
密度 | 1.38±0.1 g/cm3(Predicted) |
储存条件 | -20°C |
酸度系数(pKa) | 3.32±0.10(Predicted) |
旋光性 (optical activity) | [α]22/D +55.0°, c = 1% in chloroform |
InChIKey | OXLCJWGAUPPZQJ-ZNHCDWFHSA-N |
The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome.
安全信息
WGK Germany | 3 |
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海关编码 | 2932 99 00 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-P0232 | N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH | 116783-35-8 | 25mg | 1900元 |
2024/01/25 | HY-P0232 | N-芴甲氧羰基-O-BETA-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-ALPHA-D-吡喃半乳糖基)-L-苏氨酸 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH | 116783-35-8 | 50mg | 3040元 |