METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-
| 中文名称 | METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)- |
|---|---|
| 中文同义词 | 6-羟基苯溴马隆;BENZBROMARONE杂质7-13C3-D2(6-羟基-BENZBROMARONE-13C3-D2);苯溴马隆杂质7(6-羟基苯溴马隆);6-羟基苯并溴马隆;6-羟基苯溴马隆-13C3-D2;苯溴马隆杂质10(6-羟基苯溴马隆) |
| 英文名称 | (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxybenzofuran-3-yl)methanone |
| 英文同义词 | (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxybenzofuran-3-yl)methanone;METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-;Benzbromarone Impurity 7 (6-Hydroxy-Benzbromarone);Benzbromarone 6-Hydroxy Impurity;Benzbromarone Impurity 10 (6-Hydroxy-Benzbromarone）;Benzbromarone Impurity 10;BenzbromaroneImpurity7-13C3-d2;BenzbromaroneImpurity7-13C6 |
| CAS号 | 152831-00-0 |
| 分子式 | C17H12Br2O4 |
| 分子量 | 440.08 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 152831-00-0.mol |
| 结构式 |  |
METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)- 性质
| 沸点 | 444.9±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.785±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 4.53±0.25(Predicted) |
6-Hydroxybenzbromarone 是 Benzbromarone 的主要代谢产物 (metabolite)，比母体化合物具有更长的半衰期和更大的药理效力。6-Hydroxybenzbromarone 是一种 EYA3 抑制剂，IC50 值为 21.5 μM。6-Hydroxybenzbromarone 是一种血管生成剂，对细胞迁移，肾小管生成和血管生成具有强大的抑制作用。
IC50: 21.5 μM (EYA3); metabolite
6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding.
Cell Proliferation Assay
| Cell Line: | HUVEC cells |
| Concentration: | 7.5 μM |
| Incubation Time: | 72 hours |
| Result: | Inhibited HUVEC cells proliferation. |