- Clopamide
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- $15.00 / 1KG
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2021-08-12
- CAS:636-54-4
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Clopamide Basic information |
| | Clopamide Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 42/43 | | Safety Statements | 36 | | WGK Germany | 3 |
| | Clopamide Usage And Synthesis |
| Chemical Properties | White or almost white, hygroscopic, crystalline powder | | Originator | Brinaldix,Novartis | | Uses | Antihypertensor;Gonad stimuling agent | | Uses | Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only. | | Uses | Antihypertensive; diuretic. | | Definition | ChEBI: 4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide. | | Manufacturing Process | To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml
chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly
was added at room temperature. Reaction mixture was heated to 100°-105°C
during 8 h, then it was cooled to room temperature. The precipitated crystals
of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide
were filtered and dried at 100°C under vacuo, then was treated by ammonium
at room temperature. The obtained product was chromatographed (aluminum
oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis-
2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point
235°-237°C. | | Brand name | Aquex (Novartis). | | Therapeutic Function | Diuretic, Antihypertensive |
| | Clopamide Preparation Products And Raw materials |
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