P11
中文名称 | P11 |
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中文同义词 | HSDVHK-NH2;H-HIS-SER-ASP-VAL-HIS-LYS-NH2;抑制剂多肽P11 |
英文名称 | P11 |
英文同义词 | L-Lysinamide, L-histidyl-L-seryl-L-α-aspartyl-L-valyl-L-histidyl- (9CI);P11 ( (trifluoroacetate salt) |
CAS号 | 848644-86-0 |
分子式 | C30H48N12O9 |
分子量 | 720.79 |
EINECS号 | |
相关类别 | |
Mol文件 | 848644-86-0.mol |
结构式 |
P11 性质
沸点 | 1380.0±65.0 °C(Predicted) |
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密度 | 1.381±0.06 g/cm3(Predicted) |
储存条件 | -20°C, protect from light |
溶解度 | 在 20% 乙腈 - 0.1% 乙酸中溶解度为 1 mg/ml |
形态 | 粉末 |
酸度系数(pKa) | 4.17±0.10(Predicted) |
序列 | H-His-Ser-Asp-Val-His-Lys-NH2 |
αvβ3 2.74 nM (IC 50 ) |
HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group.
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC
50
value of 25.72 nM.
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression.
Cell Proliferation Assay
Cell Line: | HUVEC cells. |
Concentration: | 0.1, 1, 10, and 100 μg/mL. |
Incubation Time: | 72 h. |
Result: | Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner. |
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%