3-DEAZAADENOSINE HYDROCHLORIDE
中文名称 | 3-DEAZAADENOSINE HYDROCHLORIDE |
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中文同义词 | 3-脱氮腺苷盐酸盐;化合物3-DEAZAADENOSINE HYDROCHLORIDE |
英文名称 | 3-Deazaadenosine (hydrochloride) |
英文同义词 | 3-Deazaadenosine (hydrochloride);3-Deaza-rA?HCl;HIV,3-Deazaadenosine,Human immunodeficiency virus,Inhibitor,3 Deazaadenosine hydrochloride,3Deazaadenosine hydrochloride,inhibit;1H-Imidazo[4,5-c]pyridin-4-amine,1-β-Dribofuranosyl-,monohydrochloride |
CAS号 | 86583-19-9 |
分子式 | C11H15ClN4O4 |
分子量 | 302.72 |
EINECS号 | |
相关类别 | |
Mol文件 | 86583-19-9.mol |
结构式 |
3-DEAZAADENOSINE HYDROCHLORIDE 性质
储存条件 | Store at -20°C |
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溶解度 | DMSO:30mg/mL; PBS(pH 7.2):10 mg/mL |
形态 | 结晶固体 |
Target | Value |
S-adenosylhomocysteine hydrolase
(Cell-free assay) | 3.9 μM(Ki) |
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K i of 3.9 µM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 µM, respectively. 3-Deazaadenosine (1-100 µM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 µM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 µM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 µM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-W013332A | 3-DEAZAADENOSINE HYDROCHLORIDE 3-Deazaadenosine hydrochloride | 86583-19-9 | 1mg | 1713元 |
2024/04/30 | HY-W013332A | 3-DEAZAADENOSINE HYDROCHLORIDE 3-Deazaadenosine hydrochloride | 86583-19-9 | 10mM * 1mLin DMSO | 2597元 |