FT-113 manufacturers
- FT113
-
- $31.00 / 5mg
-
2025-11-10
- CAS:1630808-89-7
- Min. Order:
- Purity: 97.68%
- Supply Ability: 10g
|
| Product Name: | FT-113 | | Synonyms: | FT-113;FT113;F113;FT 113;Methanone, [4-[4-(6-fluoro-2-benzoxazolyl)benzoyl]-1-piperazinyl](1-hydroxycyclopropyl)-;FT 113,Fatty Acid Synthase (FASN),Inhibitor,FT-113,FT113,inhibit;(4-(4-(6-Fluorobenzo[d]oxazol-2-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone;FT113, 10 mM in DMSO | | CAS: | 1630808-89-7 | | MF: | C22H20FN3O4 | | MW: | 409.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1630808-89-7.mol |  |
| | FT-113 Chemical Properties |
| Boiling point | 637.6±55.0 °C(Predicted) | | density | 1.456±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 62.5 mg/mL (152.66 mM; Need ultrasonic) | | pka | 13.92±0.20(Predicted) | | form | Solid | | color | White to off-white | | InChI | InChI=1S/C22H20FN3O4/c23-16-5-6-17-18(13-16)30-19(24-17)14-1-3-15(4-2-14)20(27)25-9-11-26(12-10-25)21(28)22(29)7-8-22/h1-6,13,29H,7-12H2 | | InChIKey | DSTWHRGOCUOKDE-UHFFFAOYSA-N | | SMILES | C(N1CCN(C(=O)C2=CC=C(C3=NC4=CC=C(F)C=C4O3)C=C2)CC1)(C1(O)CC1)=O |
| | FT-113 Usage And Synthesis |
| Uses | FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo[1]. | | in vivo | FT113 (5 mg/kg, p.o.) exhibits potent oral bioavailability of 95% and 84% in mice and rats, respectively[1].
?
FT113 (5, 25, or 50 mg/kg, p.o., twice daily for 16 days) increases malonyl-CoA concentration in tumors, inhibits tumor growth in a dose-dependent manner in mice[1]. | Animal Model: | Athymic nude mice bearing MV-411 cells[1] | | Dosage: | 5, 25, or 50 mg/kg | | Administration: | P.O., twice daily for 16 days | | Result: | Caused 32 % and 50% tumor growth inhibition at 25 and 50 mg/kg, respectively in mice. |
| | References | [1] Martin MW, et al. Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). Bioorg Med Chem Lett. 2019 Apr 15;29(8):1001-1006. DOI:10.1016/j.bmcl.2019.02.012 |
| | FT-113 Preparation Products And Raw materials |
|