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2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide

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2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide Suppliers list
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:CPD3616 CPD-3616
CAS:2140807-05-0
Purity:99% Package:5KG;1KG Remarks:CPD3616 CPD-3616
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
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Email: sales@chemhifuture.com
Products Intro: Product Name:CPD3616
CAS:2140807-05-0
Purity:0.98 Package:5mg，10mg，100mg，500mg，1g，5g，10g，more
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
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Products Intro: Product Name:(Rac)-JBJ-04-125-02；JBJ-04-125-02
CAS:2140807-05-0
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Guangzhou Tosun Pharmaceutical Limited
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Email: info@upharm.cn
Products Intro: Product Name:Compounds jbj-04-125-02
CAS:2140807-05-0
Package:5mg
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:JBJ-04-125-02
CAS:2140807-05-0
Purity:98%+ Package:500mg;1g;500g；1kg Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide Basic information
Product Name:2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide
Synonyms:2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide;CPD3616;JBJ-04-125-02;(Rac)-JBJ-04-125-02;2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-6-[4-(1-piperazinyl)phenyl]-N-2-thiazolyl-;Allosteric,anti-proliferation,HER1,inhibit,ErbB-1,(Rac)JBJ0412502,Inhibitor,racemate,Epidermal growth factor receptor,anti-tumor,(Rac) JBJ 04 125 02,EGFR,T790M-mutant;Compounds jbj-04-125-02;CPD3616 CPD-3616
CAS:2140807-05-0
MF:C29H26FN5O3S
MW:543.61
EINECS:
Product Categories:
Mol File:2140807-05-0.mol
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide Structure
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide Usage And Synthesis
Uses(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor[1].
IC 50EGFR (L858R/T790M): 0.26 nM (IC50)
References[1] To C, et al. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 Jul;9(7):926-943. DOI:10.1158/2159-8290.CD-18-0903
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide Preparation Products And Raw materials
Tag:2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide(2140807-05-0) Related Product Information
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