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LGM Pharma
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1-(800)-881-8210 |
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| Products Intro: |
Product Name:Benfluorex
CAS:23602-78-0
Purity:Typically NLT 98%
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BENFLUOREX HYDROCHLORIDE manufacturers
- BENFLUOREX HYDROCHLORIDE
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- $2.00 / 1KG
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2020-01-08
- CAS:23602-78-0
- Min. Order: 1KG
- Purity: 97%
- Supply Ability: 100g , 1kg, 5kg , 50kg
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| | BENFLUOREX HYDROCHLORIDE Basic information |
| Product Name: | BENFLUOREX HYDROCHLORIDE | | Synonyms: | Ethanol, 2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]-, benzoate;jp992;Minolip;n-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethyl-phenethylaminbenzoate;N-(2-Hydroxyethyl)-alpha-methyl-m-trifluoromethylphenethylamine benzoate;n-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethylphenethylaminebenzoate;Phenethylamine, N-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethyl-, benzoate;s780 | | CAS: | 23602-78-0 | | MF: | C19H20F3NO2 | | MW: | 351.36 | | EINECS: | 245-777-9 | | Product Categories: | MINOLIP | | Mol File: | 23602-78-0.mol |  |
| | BENFLUOREX HYDROCHLORIDE Chemical Properties |
| Boiling point | 420.5±45.0 °C(Predicted) | | density | 1.183±0.06 g/cm3(Predicted) | | pka | 8.23±0.10(Predicted) |
| WGK Germany | 2 | | RTECS | KL8275000 | | Toxicity | LD50 oral in mouse: 2300mg/kg |
| | BENFLUOREX HYDROCHLORIDE Usage And Synthesis |
| Originator | Mediator,Servier,France,1976 | | Uses | antihyperlipoproteinemic | | Definition | ChEBI: Benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester is a benzoate ester. | | Manufacturing Process | To a solution of 24.7 parts of 1-(m-trifluoromethylphenyl)-2-(β-
hydroxyethyl)amino propane in 140 parts of anhydrous benzene, there were
added successively 15 parts of 4.7N hydrochloric ether and a solution of 14
parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition
required 10 minutes, the reaction mixture was then refluxed for 8 hours.
The solid product was collected by filtration and after recrystallization from
230 parts of ethyl acetate, there were obtained 15 parts of 1-(mtrifluoromethylphenyl)-
2-(β-benzoyloxyethyl)amino propane hydrochloride
melting at 161°C.
10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts
ether are added, then 10 parts of a concentrated solution of ammonium
hydroxide. The mixture is stirred a few minutes until the salt is dissolved,
then the ethered solution is poured off and dried. After the ether is
eliminated, 9 parts of 1-(m-trifluoromethylphenyl)-2-(β-
benzoyloxyethyl)amino propane are obtained; the base is a colorless oil. | | Therapeutic Function | Antihyperlipidemic, Cardiovascular |
| | BENFLUOREX HYDROCHLORIDE Preparation Products And Raw materials |
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