2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-

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Products Intro: Product Name:GSK-3β inhibitor 1
CAS:187325-53-7
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CAS:187325-53-7
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Products Intro: Product Name:GSK-3β inhibitor 1
CAS:187325-53-7
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CAS:187325-53-7
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2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- manufacturers
2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Basic information
Product Name:2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-
Synonyms:2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-;GSK-3β inhibitor 1;GSK-3,inhibit,Glycogen synthase kinase 3,Glycogen synthase kinase-3,GSK3β inhibitor 1,GSK-3β inhibitor 1,Inhibitor,GSK 3β inhibitor 1;(Z)-3-(Pyridin-2-ylmethylene)indolin-2-one;(3Z)-3-(2-pyridinylmethylene)-1,3-dihydro-2H-indol-2-one
CAS:187325-53-7
MF:C14H10N2O
MW:222.24
EINECS:
Product Categories:
Mol File:187325-53-7.mol
2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Structure
2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Chemical Properties
Boiling point 457.2±45.0 °C(Predicted)
density 1.291±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka12.34±0.20(Predicted)
form Solid
color Yellow to orange
InChIInChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-
InChIKeyYKQONSWBHGBDSB-XFXZXTDPSA-N
SMILESN1C2=C(C=CC=C2)/C(=C/C2=NC=CC=C2)/C1=O
Safety Information
MSDS Information
2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Usage And Synthesis
UsesGSK-3β inhibitor 1 (compound 3a) inhibits GSK-3β with an IC50 of 4.19 nM. GSK-3β inhibitor 1 demonstrates high antidiabetic efficacy in obese Streptozotocin (HY-13753)-treated rats[1].
in vivo

GSK-3β inhibitor 1 (50 mg/kg, i.p., 30 min prior to glucose challenge) effectively prevents increase in blood glucose levels in HFD+STZ diabetic rats[1].

Animal Model:HFD+STZ diabetic rats [1] .
Dosage:50 mg/kg
Administration: i.p., 30 min prior to glucose challenge
Result:Vehicle-treated diabetic rats developed persistent hyperglycemic response. Administration of GSK-3β inhibitor 1 30 min prior to glucose challenge effectively prevented increase in blood glucose levels.
IC 50GSK-3β: 4.9 nM (IC50)
References[1] Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817. DOI:10.1016/j.bmc.2019.03.028
2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Preparation Products And Raw materials
Tag:2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-(187325-53-7) Related Product Information
(Z)-3-((2-Aminophenyl)(1H-indol-2-yl)methylene)-1-(naphthalen-2-ylmethyl)indolin-2-one NA 3-phenyl-1,5-naphthyridin-2-ol 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- 1H-Pyrrole-3-carboxamide, 5-[(Z)-[5-[(aminocarbonyl)amino]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-N-[2-(dimethylamino)ethyl]- Urea, N-[2,3-dihydro-2-oxo-3-[(3Z)-1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]-