ANTI-NF-KB P65抗体

ANTI-NF-KB P65抗体

中文名称ANTI-NF-KB P65抗体
中文同义词ANTI-NF-KB P65抗体
英文名称Anti-NF-kB p65 Antibody
英文同义词Anti-NF-kB p65 Antibody
CAS号
分子式
分子量0
EINECS号
相关类别
Mol文件Mol File
结构式ANTI-NF-KB P65抗体 结构式

ANTI-NF-KB P65抗体 性质

ANTI-NF-KB P65抗体 用途与合成方法

Anti-NF-kB p65 Antibody, Mouse Monoclonal

Mouse

ELISA,FCM,ICC/IF

Human

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RELA / Transcription factor p65 (rh RELA / Transcription factor p65; Catalog#12054-H09E; Q04206-1; Met 1-Tyr 306). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Anti-NF-kB p65 Antibody, Mouse Monoclonal---Cat: 12054-MM04
Anti-NF-kB p65 Antibody
Immunofluorescence staining of human RELA (NF-KB p65) in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 1% Triton X-100 in PBS, blocked with 10% serum, and incubated with Mouse anti-human RELA monoclonal antibody (1:100) at 4℃ overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm.

RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p5 and its precursor p15), and NF-kappaB2 (p52 and its precursor p1), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.NF-κB(核因子激活的B细胞的κ-轻链增强)是一种蛋白质复合物,其控制转录的DNA,细胞因子产生和细胞存活。NF-κB几乎存在于所有动物细胞类型中,并参与细胞对刺激的反应,如应激,细胞因子,自由基,重金属,紫外线照射,氧化LDL和细菌或病毒抗原。NF-κB在调节对感染的免疫应答中起关键作用。NF-κB的不正确调节与癌症,炎症和自身免疫疾病,感染性休克,病毒感染和免疫发育不当有关。NF-κB也与突触可塑性和记忆过程有关。ANTI-NF-KB P65抗体是一类可以特异性结合ANTI-NF-KB P65的克隆抗体,主要用于检测ANTI-NF-KB P65的Western Blot、IHC-P、IF、ELISA、Co-IP等多种免疫学实验。

安全信息

MSDS信息

ANTI-NF-KB P65抗体 上下游产品信息

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