5-氨基-1-甲基喹啉-1-鎓碘化物
中文名称 | 5-氨基-1-甲基喹啉-1-鎓碘化物 |
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中文同义词 | 5-氨基-1-甲基喹啉-1-碘化物;5-氨基-1-甲基喹啉碘代物;5-氨基-1甲基喹啉碘化物;5-氨基-1-甲基喹啉-1-鎓碘化物;化合物NNMTI;1-甲基-5-氨基喹啉碘代物;5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE;5-AMINO-1MQ;NNMTI,烟酰胺N-甲基转移酶抑制剂 |
英文名称 | NNMTi |
英文同义词 | 5-amino-1-methylquinolin-1-ium iodide;5-Amino-1methylquinolinium iodide;5-amino-1MQ;NNMTi;5-Amino-1-methylquinolinium;NNMTi,inhibit,fusion,muSC,muscle stem cell,NNMT,Inhibitor,regenerative;NNMTi 5-amino-1MQ;1-methylquinolin-1-ium-5-amine iodide |
CAS号 | 42464-96-0 |
分子式 | |
分子量 | 0 |
EINECS号 | |
相关类别 | 化学试剂 |
Mol文件 | Mol File |
结构式 |
5-氨基-1-甲基喹啉-1-鎓碘化物 性质
熔点 | 213-214 °C |
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储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
NNMTi (10-30 µM; 96 hours) produces a concentration-related increase in myoblast differentiation on C2C12 myoblast differentiation. 30 µM NNMTi results in 18% MHC-positive myotube nuclei, representing a 45% increase in the extent of myoblast differentiation compared to untreated differentiating myoblasts (12% MHC-positive myotube nuclei).
NNMTi (subcutaneous (SC) injection; 5 mg/kg and 10 mg/kg; 2 weeks (1 week pre-injury and 1 week post-injury)) has an effect on muscle regeneration after injury, it results in 60% and 75% higher incidence of proliferating/active muSCs at 5 mg/kg and 10 mg/kg, respectively. The relative numbers of fibers with an EdU + myonucleus increased 40% and 48% with NNMTi treatment at 5 mg/kg and 10 mg/kg, respectively. The odds ratio of fused myonuclei for control are 0.58 and 0.53 times the odds at the low and high NNMTi dose, respectively.NNMTi (subcutaneous injection; 10 mg/kg; 1 week) produces no systemic toxicity in mice, the levels of the glucose, cholesterol, plasma proteins, and electrolytes between control and NNMTi-treated samples show no difference in mice. 1-week post-injury daily repeat-dosing of NNMTi is well tolerated with no untoward systemic toxicity or behavioral implications in aged mice.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-131042 | 5-氨基-1-甲基喹啉-1-鎓碘化物 NNMTi | 42464-96-0 | 10mM * 1mLin DMSO | 660元 |
2024/04/30 | HY-131042 | NNMTi | 10 mg | 860元 |