Company Name: |
FRESENIUS KABI IPSUM SRL
|
Tel: |
+39 02 92 46 291 (6 lines) |
Email: |
alessandro.cescut@fresenius-kabi.com |
Products Intro: |
Product Name:PIVMECILLINAM HYDROCHLORIDE
|
Company Name: |
United States Biological
|
Tel: |
800.520.3011 or 781.639.5092 |
Email: |
chemicals@usbio.net |
Products Intro: |
Product Name:Pivmecillinam Hydrochloride
|
Company Name: |
AUROBINDO PHARMA LIMITED
|
Tel: |
+91 (40) 6672 1200 |
Email: |
info@aurobindo.com |
Products Intro: |
Product Name:Pivmecillinam hydrochloride
|
Company Name: |
FRESENIUS KABI IPSUM S.R.L.
|
Tel: |
+39 02 92 46 291 |
Email: |
raffaella.cristiani@fresenius-kabi.com |
Products Intro: |
Product Name:Pivmecillinam hydrochloride
|
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| PIVMECILLINAM HYDROCHLORIDE Basic information |
| PIVMECILLINAM HYDROCHLORIDE Chemical Properties |
| PIVMECILLINAM HYDROCHLORIDE Usage And Synthesis |
Uses | Pivmecillinam is an orally active prodrug of Amdinocillin (A576300), an broad spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2. | Clinical Use | Antibacterial agent | Drug interactions | Potentially hazardous interactions with other drugs
Antiepileptics: avoid concomitant use with valproate.
Methotrexate: penicillins can reduce the excretion of
methotrexate (increased risk of toxicity).
Probenecid: reduces excretion of penicillins. | Metabolism | Pivmecillinam is rapidly hydrolysed to mecillinam which
is the active drug, plus pivalic acid and formaldehyde.
About 45% of a dose may be excreted in the urine as
mecillinam, mainly within the first 6 hours. Mecillinam
is partly excreted with bile, giving rise to biliary
concentrations about 3 times the serum levels. |
| PIVMECILLINAM HYDROCHLORIDE Preparation Products And Raw materials |
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