DI-8-ANEPPS
| 中文名称 | DI-8-ANEPPS |
|---|---|
| 中文同义词 | 膜电位荧光探针DI-8-ANEPPS;DI-8-ANEPPS(膜电位荧光探针);4-[2-[6-(二辛基氨基)-2-萘基]乙烯基]-1-(3-磺基丙基)-吡啶鎓内盐;3-(4-(2-(6-(二辛基氨基)萘-2-基)乙烯基)吡啶-1-鎓-1-基)丙烷-1-磺酸盐;DI-8-ANEPPS,一种电压敏感染料;化合物 DI-8-ANEPPS;迪-8-ANEPPS;Di-8-ANEPPS,电位探针 (Di-8-ANEPPS, potentiometric probe) |
| 英文名称 | Di-8-anepps |
| 英文同义词 | 4-(2-[6-(DIOCTYLAMINO)-2-NAPHTHALENYL]ETHENYL)-1-(3-SULFOPROPYL)PYRIDINIUM INNER SALT;Jpw 1153;Di-8-ANEPPS *CAS#: 157134-53-7*;Pyridinium, 4-[2-[6-(dioctylamino)-2-naphthalenyl]ethenyl]-1-(3-sulfopropyl)-, inner salt;3-(4-(2-(6-(Dioctylamino)naphthalen-2-yl)vinyl)pyridin-1-ium-1-yl)propane-1-sulfonate;4-amino-1-((2R,3R,4R,5S)-4-azido-5-(hydroxymethyl)-3-(2-(trifluoromethoxy)ethoxy)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;Di-8-ANEPPS Membrane Potential Probe;Di-8-anepps |
| CAS号 | 157134-53-7 |
| 分子式 | C36H52N2O3S |
| 分子量 | 592.87 |
| EINECS号 | |
| 相关类别 | 荧光探针，标记，颗粒和染色;分析试剂-显色剂;生化试剂;化工;Styryl |
| Mol文件 | 157134-53-7.mol |
| 结构式 |  |
DI-8-ANEPPS 性质
| 熔点 | >200℃ |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于DMSO |
| 形态 | 粉末 |
| 颜色 | 橙色至红色 |
| 外观 | Orange solid |
| 激发峰(Ex)/发射峰(Em) | 468/633 nm (artificial membrane) |
| 最大波长(λmax) | 498 nm |
| ε(消光系数) | ≥37 at 495-501 nm in methanol |
| 主要应用 | 诊断试剂生产 血液学 组织学 |
| 生物领域应用 | Measuring membrane potential |
| InChIKey | IXFSUSNUALIXLU-UHFFFAOYSA-N |
| SMILES | CCCCCCCCN(CCCCCCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1 |
Di-8-ANEPPS 是萘基苯乙烯基（ANEP）电压敏感染料，它们的荧光激发和发射光谱会因电压的变化而变化。相对于Di-4-ANEPPS，Di-8-ANEPPS有更长的碳链尾巴，更容易驻留在细胞膜双脂层的外层，可胜任长时间的电压检测实验。Di-8-ANEPPS比Di-4-ANEPPS光学性质更稳定，光毒性更小。膜电位荧光探针Di-8-ANEPPS 是萘基苯乙烯基电压敏感染料，它们的荧光激发和发射光谱会因电压的变化而变化。
ex/em : 468/633 nm (人工膜)
消光系数(ε) : 44,000 L⋅mol−1⋅cm−1 (甲醇)
A mouse cell staining with Di-8-ANEPPS is applied voltage clamp pulses and immersed in Na + -containing solution. The Di-8-ANEPPS signal, which largely reflects t system voltage, has an asymmetrical positive component upon application of depolarizing pulses. This is interpreted as reflecting a propagating action potential, escaping from the voltage-clamped plasma membrane. Its temporal properties are not unlike those of the “center” signal. Notably, the peak of the signal occurrs 0.3 ms after the leading edge of the depolarizing pulse.
化学性质
外观 : 橘红色固体ex/em : 468/633 nm (人工膜)
消光系数(ε) : 44,000 L⋅mol−1⋅cm−1 (甲醇)
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-101891 | DI-8-ANEPPS Di-8-ANEPPS | 157134-53-7 | 1mg | 572元 |
| 2026/09/15 | HY-101891 | DI-8-ANEPPS Di-8-ANEPPS | 157134-53-7 | 5 mg | 1859元 |