| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:SoMbrevin
CAS:1421-14-3
Package:500Mg,5g
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| | propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate Basic information |
| | propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate Chemical Properties |
| Boiling point | bp0.7 210-212° | | density | 1.2043 (rough estimate) | | refractive index | 1.5000 (estimate) | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Ethyl Acetate (Slightly) | | form | Oil | | color | Pale Yellow to Yellow | | EPA Substance Registry System | Propanidid (1421-14-3) |
| Toxicity | LD50 orally in rats: >10,000 mg/kg (Goldenthal) |
| | propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate Usage And Synthesis |
| Chemical Properties | yellow oil bp0.7 210-212°C soluble in alcohol, chloroform, essentially water insoluble anasthetic Epontol (Bayer) Sombrevin | | Uses | Sombrevin, is an ultra short-acting phenylacetate general anesthetic. | | Uses | Anesthetic (intravenous). | | Definition | ChEBI: Propanidid is a member of methoxybenzenes. | | Brand name | Epontol (Farbenfabriken
Bayer A.G., Germany). | | Clinical Use | Propanidid is used as a very short- to shortacting
intravenous anesthetic for minor surgery
and gynecology. It is characterized by rapid
onset of and quick recovery from anesthesia,
producing surgical anesthesia for 3 – 4 min. Repeated
injections can be used to prolong the
anesthesia. Postanesthetic sleep does not occur
because the propyl ester is hydrolyzed rapidly
in the patient to form inactive 3-methoxy-4-
(N,N-diethylcarbamoylmethoxy)phenylacetic
acid. After 20 – 30 min the patients generally
are completely responsive . | | Synthesis | Propanidid , propyl 3-
methoxy-4-(N,N-diethylcarbamoylmethoxy)-
phenylacetate, is a colorless to pale
yellowish water-insoluble oil. It is prepared
from the propyl ester of sodium homovanillic
acid and N,N-diethylchloroacetamide .
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| | propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate Preparation Products And Raw materials |
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