| | morclofone Basic information |
| Product Name: | morclofone | | Synonyms: | morclofone;4'-Chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone;4'-chloro-3,5-dimethoxy-4-(2-morpholin-4-yl-ethoxy)-benzophenone;Methanone, (4-chlorophenyl)[3,5-dimethoxy-4-[2-(4-morpholinyl)ethoxy]phenyl]- | | CAS: | 31848-01-8 | | MF: | C21H24ClNO5 | | MW: | 405.87 | | EINECS: | 250-838-8 | | Product Categories: | | | Mol File: | 31848-01-8.mol |  |
| | morclofone Chemical Properties |
| Melting point | 91-92° | | Boiling point | 563.1±50.0 °C(Predicted) | | density | 1.220±0.06 g/cm3(Predicted) | | pka | 6.28±0.10(Predicted) |
| Toxicity | LD50 orally in mice: 552 mg/kg (Lauria) |
| | morclofone Usage And Synthesis |
| Originator | Plausitin,Carlo Erba,Italy,1975 | | Definition | ChEBI: Morclofone is a member of benzophenones. | | Manufacturing Process | Sodium methoxide (1.2 g) in dimethylformamide (150 ml) was stirred with
3,5-dimethoxy-4'-chloro-4-hydroxybenzophenone (6 g) in dimethylformamide
(50 ml), for 2 hours at 120°C. The reaction mixture was then treated with β-
morpholinoethyl chloride (3.4 g) and heated for 1 hour at 140C, then
evaporated to dryness, and treated with water to give a solid material. The
mixture was filtered, washed and crystallized from cyclohexane to give 3,5-
dimethoxy-4'-chloro-4-(β-morpholinoethoxy)-benzophenone (6.5 g), MP 91°C
to 92°C. The product was then reacted at about 0°C with gaseous hydrogen
chloride in ether to give, after crystallization from isopropanol, the
corresponding hydrochloride which had a MP of 187.9°C. | | Therapeutic Function | Antitussive |
| | morclofone Preparation Products And Raw materials |
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