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Meenaakshi Molecules Pvt Ltd
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+91-9121311126 +91-9121311126 |
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Products Intro: |
Product Name:Zilpaterol CAS:119520-05-7 Purity:99% Package:5 kg, 25 Kg, 50 kg,100 kg and 1 MT
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Company Name: |
TianJin Alta Scientific Co., Ltd.
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022-65378550-8551 |
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contact@altascientific.com |
Products Intro: |
Product Name:Zilpaterol CAS:119520-05-7 Purity:99% Package:10Mg, 100Mg, 1g
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| ZILPATEROL HYDROCHLORIDE Basic information |
Product Name: | ZILPATEROL HYDROCHLORIDE | Synonyms: | ZIPATEROL HYDROCHLORIDE (FOR RESEARCH ONLY);(-trans-4,5,6,7-Tetrahydro-7-hydroxy-6-(isopropylamino)imidazo[4,5,1-jk][1]benzazepin-2(1H)-one;RU-4217;zilpa;ZILPATEROLHYDROCHLORIDEMONOHYDRATE(FORR&DONLY);RU-42173;Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, (6R,7R)-rel-;Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, trans-( -)- | CAS: | 119520-05-7 | MF: | C14H19N3O2 | MW: | 261.32 | EINECS: | 924-535-2 | Product Categories: | Agro-Products;Chiral Reagents;Heterocycles | Mol File: | 119520-05-7.mol | |
| ZILPATEROL HYDROCHLORIDE Chemical Properties |
Melting point | 123-126°C | density | 1.29±0.1 g/cm3(Predicted) | storage temp. | -20°C Freezer, Under Inert Atmosphere | solubility | ≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide | form | crystalline solid | pka | 13.39±0.60(Predicted) | Stability: | Temperature Sensitive | CAS DataBase Reference | 119520-05-7 |
| ZILPATEROL HYDROCHLORIDE Usage And Synthesis |
Chemical Properties | Yellow Solid | Uses | Zilpaterol is a β-Adrenergic agonist. Growth promotant. | Uses | Zilpaterol is a β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues. It was approved by the FDA in 2006 as a veterinary food additive for the purpose of increasing lean body weight and improving feed efficiency in commercial beef cattle. | Definition | ChEBI: Zilpaterol is a benzazepine. | Biological Activity | zilpaterol is a β-adrenergic receptor agonist.β-adrenergic receptors, prototypic g-protein-coupled receptors, play a key role in regulating numerous physiological processes. | in vitro | previus study found that there was no effect of zilpaterol (zh) on thymidine incorporation into dna. zh at 1 μm could decrease β1-ar mrna, and 0.01 and 1 μm zh decreased β2-ar and β3-ar mrna in myoblasts. there was no effect of zh on the β-ar or igf-i gene expression in fused myotube cultures. the β2-ar antagonist ici-118, 551 attenuated the effect of zh to reduce expression of β1- and β2-ar mrna. there was no effect of ici-118, 551 or zh on β3-ar or igf-i. in addition, the total lipid synthesis from acetate was increased by zh in bovine subcutaneous adipose tissue explants in the absence of theophylline [1]. | in vivo | fda has approved label claims of increased rate of bw gain, improved feed efficiency, and increased carcass leanness. the feeding of zh for 20 to 40 d with a 3-d withdrawal resulted in significantly increased adg. such increases equate to an average of 9 kg heavier bw in zh-fed steers. moreover, hot carcass weight has been shown to increase to a larger degree compared with bw, with an average improvement of 15 kg [2]. | references | [1] miller, e. k.,chung, k.y.,hutcheson, j.p., et al. zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. journal of animal science 90(4), 1317-1327 (2012). [2] delmore, r. j.,hodgen, j.m. and johnson, b.j. perspectives on the application of zilpaterol hydrochloride in the united states beef industry. journal of animal science 88(8), 2825-2828 (2010). |
| ZILPATEROL HYDROCHLORIDE Preparation Products And Raw materials |
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