ZILPATEROL HYDROCHLORIDE

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Products Intro: Product Name:ZILPATEROL HYDROCHLORIDE
CAS:119520-05-7
Purity:99% Package:5KG;1KG Remarks:C14H20ClN3O2
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Products Intro: Product Name:Zilpaterol
CAS:119520-05-7
Purity:NLT 98% Remarks:MC510469
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Products Intro: Product Name:Zilpaterol
CAS:119520-05-7
Purity:99% Package:5 kg, 25 Kg, 50 kg,100 kg and 1 MT
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Products Intro: Product Name:Zilpaterol
CAS:119520-05-7
Purity:98%
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Products Intro: Product Name:Zilpaterol
CAS:119520-05-7
Purity:99% Package:10Mg, 100Mg, 1g
ZILPATEROL HYDROCHLORIDE Basic information
Product Name:ZILPATEROL HYDROCHLORIDE
Synonyms:ZIPATEROL HYDROCHLORIDE (FOR RESEARCH ONLY);(-trans-4,5,6,7-Tetrahydro-7-hydroxy-6-(isopropylamino)imidazo[4,5,1-jk][1]benzazepin-2(1H)-one;RU-4217;zilpa;ZILPATEROLHYDROCHLORIDEMONOHYDRATE(FORR&DONLY);RU-42173;Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, (6R,7R)-rel-;Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, trans-( -)-
CAS:119520-05-7
MF:C14H19N3O2
MW:261.32
EINECS:924-535-2
Product Categories:Agro-Products;Chiral Reagents;Heterocycles
Mol File:119520-05-7.mol
ZILPATEROL HYDROCHLORIDE Structure
ZILPATEROL HYDROCHLORIDE Chemical Properties
Melting point 123-126°C
density 1.29±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility ≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide
form crystalline solid
pka13.39±0.60(Predicted)
Stability:Temperature Sensitive
CAS DataBase Reference119520-05-7
Safety Information
HS Code 29339900
MSDS Information
ZILPATEROL HYDROCHLORIDE Usage And Synthesis
Chemical PropertiesYellow Solid
UsesZilpaterol is a β-Adrenergic agonist. Growth promotant.
UsesZilpaterol is a β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues. It was approved by the FDA in 2006 as a veterinary food additive for the purpose of increasing lean body weight and improving feed efficiency in commercial beef cattle.
DefinitionChEBI: Zilpaterol is a benzazepine.
Biological Activityzilpaterol is a β-adrenergic receptor agonist.β-adrenergic receptors, prototypic g-protein-coupled receptors, play a key role in regulating numerous physiological processes.
in vitroprevius study found that there was no effect of zilpaterol (zh) on thymidine incorporation into dna. zh at 1 μm could decrease β1-ar mrna, and 0.01 and 1 μm zh decreased β2-ar and β3-ar mrna in myoblasts. there was no effect of zh on the β-ar or igf-i gene expression in fused myotube cultures. the β2-ar antagonist ici-118, 551 attenuated the effect of zh to reduce expression of β1- and β2-ar mrna. there was no effect of ici-118, 551 or zh on β3-ar or igf-i. in addition, the total lipid synthesis from acetate was increased by zh in bovine subcutaneous adipose tissue explants in the absence of theophylline [1].
in vivofda has approved label claims of increased rate of bw gain, improved feed efficiency, and increased carcass leanness. the feeding of zh for 20 to 40 d with a 3-d withdrawal resulted in significantly increased adg. such increases equate to an average of 9 kg heavier bw in zh-fed steers. moreover, hot carcass weight has been shown to increase to a larger degree compared with bw, with an average improvement of 15 kg [2].
references[1] miller, e. k.,chung, k.y.,hutcheson, j.p., et al. zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. journal of animal science 90(4), 1317-1327 (2012).
[2] delmore, r. j.,hodgen, j.m. and johnson, b.j. perspectives on the application of zilpaterol hydrochloride in the united states beef industry. journal of animal science 88(8), 2825-2828 (2010).
ZILPATEROL HYDROCHLORIDE Preparation Products And Raw materials
Tag:ZILPATEROL HYDROCHLORIDE(119520-05-7) Related Product Information
Zilpaterol-d7 1H-1-BENZAZEPIN-5-OL, 2,3,4,5-TETRAHYDRO- 4-METHYLBENZIMIDAZOLONE Zileuton ZILPATEROL HYDROCHLORIDE