| Company Name: |
2A PharmaChem USA
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| Tel: |
(630) 737-0988 |
| Email: |
sales@2apharmachem.com |
| Products Intro: |
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| | Pengitoxin Basic information |
| Product Name: | Pengitoxin | | Synonyms: | pentaacetylgitoxin;Pentaacetate;Card-20(22)-enolide, 16-(acetyloxy)-3-[(O-3,4-di-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)- | | CAS: | 7242-04-8 | | MF: | C51H74O19 | | MW: | 991.12 | | EINECS: | 230-645-5 | | Product Categories: | | | Mol File: | 7242-04-8.mol |  |
| | Pengitoxin Chemical Properties |
| Melting point | 151-155° | | alpha | D20 +14.0 ±1.5° (c = 1.6 in pyridine) | | Boiling point | 742.94°C (rough estimate) | | density | 1.1187 (rough estimate) | | refractive index | 1.6500 (estimate) | | Water Solubility | 11.89mg/L(temperature not stated) |
| Toxicity | LD50 in mice (mg/kg): 6.4 i.p.; in rats (mg/kg): 21.0 i.v. (Foerster) |
| | Pengitoxin Usage And Synthesis |
| Originator | Pengitoxin,Shanghai Lansheng | | Manufacturing Process | Gitoxin is isolated from leaves of Digitalis purpurea L. genus Scrofphulariaceae.
10.0 g pure gitoxin are boiled under reflux with 1 L pure acetic anhydride. Gitoxin thereby goes into solution in the course of 1 h. The boiling is discontinued after 1 h and the acetic anhydride distilled off in a vacuum as completely as possible. After taking up the oily residue with 500 ml chloroform, the solution is successively washed with 200 ml of 2 N potassium bicarbonate solution, 0.1 N hydrochloric acid and water. After drying the chloroform solution with anhydrous sodium sulfate, the chloroform is first distilled off over an open flame and then on a water bath at 40°C in a vacuum, a substantially crystalline residue thereby being obtained. The 12.8 g of crude product obtained are recrystallized from 12 times the amount of a mixture of pyridine, methanol and water (25:10:65) to give rhombic crystals, melting point 151°-155°C. | | Therapeutic Function | Cardiotonic |
| | Pengitoxin Preparation Products And Raw materials |
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