头孢三唑
| 中文名称 | 头孢三唑 |
|---|---|
| 中文同义词 | 头孢三唑;头孢三唑原料;化合物 T10751 |
| 英文名称 | Cefetrizole |
| 英文同义词 | Cefetrizole;(6R,7R)-8-Oxo-7-[2-thienylacetylamino]-3-[(1H-s-triazol-3-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 8-oxo-7-[[2-(2-thienyl)acetyl]amino]-3-[(1H-1,2,4-triazol-5-ylthio)methyl]-, (6R,7R)- |
| CAS号 | 65307-12-2 |
| 分子式 | C16H15N5O4S3 |
| 分子量 | 437.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 65307-12-2.mol |
| 结构式 |  |
头孢三唑 性质
| 密度 | 1.71±0.1 g/cm3(Predicted) |
|---|---|
| 酸度系数(pKa) | 2.65±0.50(Predicted) |
Ceftezole 是一种 α-Glucosidase 抑制剂，其 IC50 和 Ki 值分别为 2.1 μM 和 0.578 μM。
IC50: 2.1 μM (α-Glucosidase)
Ki: 0.578 μM (α-Glucosidase)
In in vitro α-Glucosidase assays, Ceftezole is shown to be a reversible, non-competitive inhibitor of yeast α-glucosidase with a K i value of 5.78×10 -7 M when the enzyme mixture is pretreated with ceftezole.
Using an in vivo streptozotocin-induced mouse model, blood glucose levels are confirmed to be decreased by 30% 20 min after Ceftezole treatment (10 mg/kg/day). Expression levels of glycogen synthase kinase-3, peroxisome proliferator-activated receptor-γ, and uncoupling protein-3 mRNA are also slightly decreased compare to controls following Ceftezole treatment.