O-(氯乙酰氨甲酰基)烟曲霉素醇
中文名称 | O-(氯乙酰氨甲酰基)烟曲霉素醇 |
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中文同义词 | TNP 470/O-(氯乙酰氨甲酰基)烟曲霉素醇;O-(氯乙酰氨甲酰基)烟曲霉素醇;[(3R,4S,5S,6R)-5-甲氧基-4-[(2R,3R)-2-甲基-3-(3-甲基丁-2-烯基)环氧乙烷-2-基]-1-氧杂螺[2.5]辛烷-6-醇] N-(2-氯乙酰基)氨基甲酸酯;甲硫氨酸氨肽酶-2抑制剂(TNP-470);夫马菌素醇;化合物 T17110;TNP-470 CALBIOCHEM;烟曲霉素杂质1 |
英文名称 | AGM-1470 |
英文同义词 | NSC642492;O-(chloroacetylcarbamoyl)fumagillol;O-(CHLOROACETYLCARBAMOYL)FUMAGILLOLTNP-470 AGM-1470;[(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate;AGM-1470;Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester;Tnp-470;N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester |
CAS号 | 129298-91-5 |
分子式 | C19H28ClNO6 |
分子量 | 401.88 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 129298-91-5.mol |
结构式 |
O-(氯乙酰氨甲酰基)烟曲霉素醇 性质
熔点 | 90-93°C |
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比旋光度 | D24 -46.6° (c = 0.44 in CHCl3) |
密度 | 1.26±0.1 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 二甲基亚砜:>15mg/mL |
酸度系数(pKa) | 7.19±0.46(Predicted) |
形态 | 白色至淡黄色固体 |
颜色 | 白色至淡黄色蜡状 |
稳定性 | 吸湿性 |
methionine aminopeptidase-2, angiogenesis
No significant difference of apoptotic cell numbers is observed between cells treated with TNP-470 and the controls. The IC 50 s of TNP-470 are 16.86±0.9 µg/mL, 3.16±0.6 µg/mL and 1.78±0.8 µg/mL for KKU-M213 cells at 24, 48 and 72 h, respectively. The results show that TNP-470 significantly reduces the number of migrated cells and invaded cells as compare with the vehicle treated group. TNP-470 decreases the migrated cells of KKU-M213 to 26% and of KKU-M214 to 11% (P<0.01). Similarly, TNP-470 also significantly affects cell invasion, the number of invaded cells is reduced to 25% in KKU-M213 (P<0.01) and to 15% in KKU-M214 (P<0.01). The relative expressions of MMP2 , MMP9 and c-MYC in TNP-470 treated cells are significantly suppressed compare to the vehicle treated cells.
Treatment with TNP-470 attenuates (P<0.05) liver lipid accumulation compare to high fat fed (HFF) mice. By day 5, TNP-470 treated mice consume significantly less grams of high fat food than vehicle treated HFF mice. By day 15 of treatment, TNP-470 mice are consuming an equivalent number of calories to that of chow fed mice, despite the provision of high fat diet. Treatment with TNP-470 increases (P<0.05) expression of adipose tissue LPL mRNA, compare to chow-fed and high-fat fed controls. TNP-470 decreases energy intake and increases energy expenditure.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-101932 | O-(氯乙酰氨甲酰基)烟曲霉素醇 TNP-470 | 129298-91-5 | 1 mg | 2800元 |
2024/01/25 | HY-101932 | O-(氯乙酰氨甲酰基)烟曲霉素醇 TNP-470 | 129298-91-5 | 5mg | 7900元 |