盐酸特拉唑嗪
| 中文名称 | 盐酸特拉唑嗪 |
|---|---|
| 中文同义词 | 特拉唑嗪标准品2-R;盐酸特拉唑嗪杂质B;(R)-特拉唑嗪 |
| 英文名称 | (R)-Terazosin |
| 英文同义词 | (R)-Terazosin;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (R)-;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI);Terazosin-002-R;(R)-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone;Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2R)-tetrahydro-2-furanyl]-;(R)-Terazosin,α1-adrenoceptor,affinity,inhibit,subtypes,prove,Adrenergic Receptor,(R)Terazosin,Inhibitor,(R) Terazosin,Low,α2-adrenoceptor,Beta Receptor |
| CAS号 | 109351-34-0 |
| 分子式 | C19H25N5O4 |
| 分子量 | 387.43 |
| EINECS号 | |
| 相关类别 | 对照品-杂质对照品;杂质对照品 |
| Mol文件 | 109351-34-0.mol |
| 结构式 |  |
盐酸特拉唑嗪 性质
| 沸点 | 664.5±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.332±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：75 mg/mL（193.58 mM） |
| 酸度系数(pKa) | 6.52±0.50(Predicted) |
Ki: 6.51 nM (α1a-adrenoceptor), 1.01 nM (α1b-adrenoceptor) and 1.97 nM (α1d-adrenoceptor)
(R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with K
i
values of 3.85 μM, 0.33 μM and 0.37 μM, respectively.
(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies.
(R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC 30 of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA 2 values of 7.5 and 5.31, respectively.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B0371B | 盐酸特拉唑嗪 (R)-Terazosin | 109351-34-0 | 5mg | 2500元 |
| 2024/01/25 | HY-B0371B | 盐酸特拉唑嗪 (R)-Terazosin | 109351-34-0 | 10mM * 1mLin DMSO | 2750元 |