次氮基三乙酸-6-异硫氰酸荧光素
| 中文名称 | 次氮基三乙酸-6-异硫氰酸荧光素 |
|---|---|
| 中文同义词 | 次氮基三乙酸-6-异硫氰酸荧光素;核杀菌素;化合物 T16361 |
| 英文名称 | nucleocidin |
| 英文同义词 | nucleocidin;5'-O-Sulfamoyl-4'-fluoroadenosine;Antibiotic T-3018;Sulfamic acid 4'-fluoro-5'-adenosyl ester;T-3018;LTBCQBSAWAZBDF-XPQPFPQWSA-N;4'-Fluoro-5'-O-sulfamoyladenosine;NSC 521007 |
| CAS号 | 24751-69-7 |
| 分子式 | C10H13FN6O6S |
| 分子量 | 364.31 |
| EINECS号 | |
| 相关类别 | Aromatics, Nucleotides, Bases & Related Reagents |
| Mol文件 | 24751-69-7.mol |
| 结构式 |  |
次氮基三乙酸-6-异硫氰酸荧光素 性质
| 熔点 | >190° (dec) |
|---|---|
| 沸点 | 747.6±70.0 °C(Predicted) |
| 密度 | 2.23±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.15±0.70(Predicted) |
Antibacterial.
Although appreciable inhibition occurrs at low concentrations of nucleocidin, it is not possible to obtain complete inhibition even at 10 -3 M. An appreciable lag occurrs before any inhibition by nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of nucleocidin. Similar results are obtained when nucleocidin is added to the cell-free system from reticulocytes. By contrast, essentially complete inhibition is obtained at 10 -3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA.
安全信息
| 毒性 | LD50 i.p. in mice: ~0.2 mg/kg (Thomas) |
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