ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7
| 中文名称 | ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7 |
|---|---|
| 中文同义词 | 拮抗剂多肽RAT CGRP-(8-37);VF-30-NH2;大鼠 CGRP-(8-37) (TFA盐);CGRP 8-37 (大鼠);(S)-4-((S)-2-(2-((S)-2-((S)-2-((2S,3R)-2-((S)-1-(L-缬氨酰-L-苏氨酰-L-组氨酰基-L-精氨酰-L-亮氨酰-L-丙氨酰甘氨酰-L-亮氨酰-L-亮氨酰-L-丝氨酰-L-精氨酰-L-丝氨酰甘氨酰甘氨酰-L-缬氨酰-L-缬氨酰-L-赖氨酰-L-天冬氨酰-L-天冬酰胺-L-苯丙氨酰-L-缬氨酰)吡咯烷-2-甲酰氨基)-3-羟基丁酰氨基)-4-氨基-4-氧代丁酰氨基)-3-甲基丁酰氨基)乙酰氨基)-3-羟基丙酰氨基)-5-(((S)-1-(((S)-1-氨基-1-氧代-3-苯基丙-2-基)氨基)-1-氧代丙-2-基)氨基)-5-氧代戊酸;CGRP(8-37)大鼠,CGRP受体拮抗肽 |
| 英文名称 | alpha-Cgrp (8-37) (rat) |
| 英文同义词 | Alpha-CGRP (8-37) (mouse, rat);α-CGRP (8-37) (mouse, rat),Calcitonin Gene-Related Peptide I (8-37) (mouse, rat), CGRP-I (8-37) (mouse, rat);α-CGRP (8-37) (mouse, rat)|Calcitonin Gene Related Peptide (8-37),rat;H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2;CALCITONIN GENE RELATED PEPTIDE (8-37) RAT;ALPHA-CALCITONIN GENE-RELATED PEPTIDE (8-37) (RAT);VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2;VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2 |
| CAS号 | 129121-73-9 |
| 分子式 | C138H224N42O41 |
| 分子量 | 3127.51 |
| EINECS号 | |
| 相关类别 | 标准品;目录多肽;Peptide;Calcitonin and CGRP receptor |
| Mol文件 | 129121-73-9.mol |
| 结构式 |  |
ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7 性质
| 密度 | 1.47±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C, protect from light |
| 溶解度 | H2O：50 mg/mL（15.99 mM；需要超声波） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble to 1 mg/ml in water |
| 序列 | H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-OH |
ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7 用途与合成方法
CGRP receptor
CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor.
CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-P0209 | ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7 Rat CGRP-(8-37) | 129121-73-9 | 500μg | 1900元 |
| 2026/09/15 | HY-P0209 | ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7 Rat CGRP-(8-37) | 129121-73-9 | 1mg | 2900元 |