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CLOXAZOLAM

CLOXAZOLAM Basic information
Product Name:CLOXAZOLAM
Synonyms:Sepazone;10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one;CLOXAZOLAM;10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one;10-Chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-oxazolo[3,2-d] [1,4]benzodiazepin-6(5H)-one;11b-tetrahydro-;Betavel;Cloxazolazepam
CAS:24166-13-0
MF:C17H14Cl2N2O2
MW:349.21
EINECS:
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:24166-13-0.mol
CLOXAZOLAM Structure
CLOXAZOLAM Chemical Properties
Melting point 202-204° (dec)
Boiling point 172°C (rough estimate)
density 1.4125 (rough estimate)
refractive index 1.6100 (estimate)
pka12.70±0.40(Predicted)
CAS DataBase Reference24166-13-0
Safety Information
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III
ToxicityLD50 in mice (g/kg): 3.3 orally; >2.0 i.p. (Kamioka)
MSDS Information
CLOXAZOLAM Usage And Synthesis
OriginatorSepazon,Sankyo,Japan,1974
UsesCLOXAZOLAM is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675). Controlled Subs tance.
DefinitionChEBI: Cloxazolam is an oxazolobenzodiazepine and a hemiaminal ether.
Manufacturing ProcessAs described in US Patent 3,772,371: To a solution of 5.8 g of 5-chloro-2- bromoacetylamino-o-chlorobenzophenone in 120 ml of ethanol were added 0.95 g of ethanolamine and 1.3 g of sodium acetate. The resulting mixture was heated under reflux for 16 hours.
After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off to give 3.25 g of the desired product melting at 202° to 204°C with decomposition.
Therapeutic FunctionTranquilizer
CLOXAZOLAM Preparation Products And Raw materials
Raw materialsMonoethanolamine
Tag:CLOXAZOLAM(24166-13-0) Related Product Information
mexazolam 2-amino-5-chloro-diphenyl methanol CLOXAZOLAM N-Methyl 4-chloro-2-(methoxymethyl)aniline (3-chlorophenyl)(phenyl)methylamine Dihydrochloride 4,5-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE (5-Chloro-2-(methylamino)phenyl)methanol (R,S)-1,3,4,5-TETRAHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE HYDROCHLORIDE 2-(2-HYDROXYETHYLAMINO)-N-(4-CHLOROPHENYL)ACETAMIDE 7-CHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE 2-AMINOBENZHYDROL C-(3-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE (2-chlorophenyl)(phenyl)methylamine 2-(AMINOMETHYL)-4-CHLORO-N-METHYLBENZENAMINE C-(2-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE