(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE
生物活性靶点体内研究 用途与合成方法 MSDS (Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE价格(试剂级) 上下游产品信息
| 中文名称 | (Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE |
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| 中文同义词 | |
| 英文名称 | (Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE |
| 英文同义词 | (Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE;LORECLEZOLE HYDROCHLORIDE;R 72063 hydrochloride |
| CAS号 | 2227372-56-5 |
| 分子式 | C10H7Cl4N3 |
| 分子量 | 310.99 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 | ![(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE 结构式](StructureFile/ChemBookStructure6/GIF/CB1227095.gif) |
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE 性质
| 溶解度 | 在 DMSO 中温和加热时溶解度为 5 mM，在乙醇中温和加热时溶解度为 5 mM |
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Loreclezole hydrochloride 是一种抗癫痫化合物，是选择性的 GABAA 受体 的调节剂，是β2 或β3亚单位包含受体的正向变构调节剂。
GABA A receptor.
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test.
| Animal Model: | Adult male Lister Hooded rats. |
| Dosage: | 10, 25, 50 or 75 mg/kg. |
| Administration: | IP, 60 min before measurement of seizure threshold. |
| Result: | Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. |