10-羟基喜树碱
中文名称 | 10-羟基喜树碱 |
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中文同义词 | 10-羟基喜树碱;10-(±)羟基喜树碱标准品;10-羟基喜树碱(CAS号:64439-81-2);160177;4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]吲哚并[1,2-B]喹啉-3,14(4H,12H)-二酮;10-(±)羟基喜树碱;10-轻基喜树碱;4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]吲哚并[1,2-B]喹啉-3,14(4H,12H)-二酮 |
英文名称 | 10-Hydroxycamptothecin |
英文同义词 | 10-HYDROXYCAMPTOTHECIN ACETATE;10-HYDROXYCAMPTOTHECIN ACETATE SALT;7-ETHYL-10-HYDROXY CAMPTHOTECIN;Hydroxy Camptothecine;77-Ethyl-10-hydroxy campthotecin;(20S)- 7-Ethyl-10-Hydroxycamptothecin;10-Hydroxycamp-totecin;7ETHYHYDROXYCAMPTOTHECIN |
CAS号 | 64439-81-2 |
分子式 | C20H16N2O5 |
分子量 | 364.35 |
EINECS号 | 613-598-9 |
相关类别 | 医药中间体;其它有机试剂;对照品,标准品;小分子抑制剂;小分子抑制剂,天然产物;Antineoplastic;喜树碱系列;Inhibitors;原料药;原料;医药、农药及染料中间体;植物提取;通用生化试剂-天然产物;科研原料;化学试剂;Camptothecin series |
Mol文件 | 64439-81-2.mol |
结构式 |
10-羟基喜树碱 性质
熔点 | 230-237°C |
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沸点 | 820.7±65.0 °C(Predicted) |
密度 | 1.60 |
储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 | 二甲基亚砜:≥37.5 mg/ml(102.92mM) |
形态 | 淡黄色粉末 |
酸度系数(pKa) | 8.93±0.40(Predicted) |
颜色 | 粘黄色 |
InChIKey | LCZZWLIDINBPRC-FQEVSTJZSA-N |
CAS 数据库 | 64439-81-2(CAS DataBase Reference) |
Target | Value |
DNA topoisomerase I
() |
(±)-10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor of topo I. (±)-10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedly inhibits the proliferation of Colo 205 cells in a dose-dependent manner. (±)-10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cells in the G2 phase of the cell cycle and triggers apoptosis through a caspase-3-dependent pathway. (±)-10-Hydroxycamptothecin (HPT, 0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation and condensed chromosomes and induces apoptosis of human urinary bladder cancer cell line (T24).
(±)-10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.) significantly suppresss tumor growth in mouse xenografts. (±)-10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4 days) causes no obvious acute toxicity in nude mice.
安全信息
危险品标志 | Xi,T |
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危险类别码 | 36/37/38-25 |
安全说明 | 26-36-45 |
危险品运输编号 | UN 2811 6.1 / PGIII |
WGK Germany | 3 |
RTECS号 | UQ0491000 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | S3898 | 10-羟基喜树碱 Hydroxy Camptothecine | 64439-81-2 | 25mg | 794.43元 |
2023/01/06 | XW196850971 | 10-羟基喜树碱 | 1g | 493元 |