5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐
中文名称 | 5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐 |
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中文同义词 | 5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐;盐酸罗替高汀;罗替高汀-D7盐酸;消旋罗替戈汀;罗替高汀消旋体;化合物 T12676;6-(PROPYL(2-(THIOPHEN-2-YL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-1-OL HYDROCHLORIDE |
英文名称 | rac-Rotigotine Hydrochloride |
英文同义词 | rac-Rotigotine Hydrochloride;1-Naphthalenol,5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-,hydrochloride;N 0437 hydrochloride;5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]-1-naphthalenol Hydrochloride;1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]-, (Hydrochloride) (1:1);Rotigotine Impurity 2(Rotigotine Racemate HCl);Rotigotine-d7 HCl;(Rac) Rotigotine hydrochloride,(Rac)Rotigotine hydrochloride |
CAS号 | 102120-99-0 |
分子式 | C19H26ClNOS |
分子量 | 351.93 |
EINECS号 | |
相关类别 | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
Mol文件 | 102120-99-0.mol |
结构式 |
5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐 性质
熔点 | >118°C (dec.) |
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储存条件 | Refrigerator |
溶解度 | 可溶于丙酮、DMSO、甲醇 |
形态 | 固体 |
颜色 | 白色至类白色 |
D 3 Receptor 0.71 nM (Ki) |
D 2 Receptor 13.5 nM (Ki) |
D 4 Receptor 3.9-15 nM (Ki) |
D 5 Receptor 5.4 nM (Ki) |
D 1 Receptor 83 nM (Ki) |
5-HT 1A Receptor 30 nM (Ki) |
5-HT 2B Receptor 27 nM (Ki) |
Rotigotine has a 10-fold selectivity for D3 (pK i =9.2) receptors compared with D2, D4 and D5 (pK i =8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pK i =7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC 50 respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (10 µM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 µM) slightly protects dopaminergic neurons against MPP+ toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone. .
安全信息
海关编码 | 2934990002 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-15394 | (Rac)-Rotigotine hydrochloride | 5 mg | 400元 | |
2024/01/25 | HY-15394 | 5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐 (Rac)-Rotigotine hydrochloride | 102120-99-0 | 10mg | 640元 |