苯甲酸 (2Z)-2-(1-己基-1,2-二氢-2-氧代-3H-吲哚-3-亚基)肼
| 中文名称 | 苯甲酸 (2Z)-2-(1-己基-1,2-二氢-2-氧代-3H-吲哚-3-亚基)肼 |
|---|---|
| 中文同义词 | N'-(1-己基-2-氧代吲哚啉-3-基亚甲基)苯甲酰肼;苯甲酸 (2Z)-2-(1-己基-1,2-二氢-2-氧代-3H-吲哚-3-亚基)肼;乙腈中MDA-19溶液;Thiocholesterol5-胆甾烯-3Β-硫醇;MDA 19 (Standard)试剂;MDA 19 (Standard)试剂;Thiocholesterol5-胆甾烯-3Β-硫醇 |
| 英文名称 | MDA 19 |
| 英文同义词 | (Z)-N'-(1-hexyl-2-oxoindolin-3-ylidene)benzohydrazide;N'-(1-Hexyl-2-oxoindolin-3-ylidene)benzohydrazide;MDA 19 (Z)-N'-(1-hexyl-2-oxoindolin-3-ylidene)benzohydrazide;MDA 19;N'-[(3Z)-1-Hexyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide;Benzoic acid (2Z)-2-(1-hexyl-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide;N-[(Z)-(1-Hexyl-2-oxo-indolin-3-ylidene)aMino]benzaMide;MDA19; MDA-19 |
| CAS号 | 1048973-47-2 |
| 分子式 | C21H23N3O2 |
| 分子量 | 349.43 |
| EINECS号 | 200-258-5 |
| 相关类别 | 定制化学品 |
| Mol文件 | 1048973-47-2.mol |
| 结构式 |  |
苯甲酸 (2Z)-2-(1-己基-1,2-二氢-2-氧代-3H-吲哚-3-亚基)肼 性质
| 密度 | 1.16±0.1 g/cm3 (20 ºC 760 Torr) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：20mg/mL； DMSO：10mg/mL；乙醇：3mg/mL；甲醇：1mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 10.45±0.20(Predicted) |
| 颜色 | 浅黄至黄色 |
MDA19 displayed 4-fold-higher affinity at the human CB(2) than at the human CB1 receptor (K(i) = 43.3 +/- 10.3 vs 162.4 +/- 7.6 nM) and nearly 70-fold-higher affinity at the rat CB2 than at the rat CB1 receptor (K(i) = 16.3 +/- 2.1 vs 1130 +/- 574 nM). In guanosine triphosphate (GTP)gamma[(35)S] functional assays, MDA19 behaved as an agonist at the human CB1 and CB2 receptors and at the rat CB1 receptor but as an inverse agonist at the rat CB2 receptor. In 3',5'-cyclic adenosine monophosphate (cAMP) assays, MDA19 behaved as an agonist at the rat CB1 receptor and exhibited no functional activity at the rat CB(2) receptor. In extracellular signal-regulated kinases 1 and 2 activation assays.
MDA19 behaved as an agonist at the rat CB2 receptor. MDA19 attenuated tactile allodynia produced by spinal nerve ligation or paclitaxel in a dose-related manner in rats and CB2(+/+) mice but not in CB2(-/-) mice, indicating that CB2 receptors mediated the effects of MDA19. MDA19 did not affect rat locomotor activity.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-15451R | 苯甲酸 (2Z)-2-(1-己基-1,2-二氢-2-氧代-3H-吲哚-3-亚基)肼 MDA 19 (Standard) | 1048973-47-2 | 5 mg | 2000元 |
| 2026/09/15 | HY-15451 | 苯甲酸 (2Z)-2-(1-己基-1,2-二氢-2-氧代-3H-吲哚-3-亚基)肼 MDA 19 | 1048973-47-2 | 5mg | 880元 |