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FRAX597

FRAX597 更多供应商
公司名称: 上海波以尔化工有限公司  
联系电话:
产品介绍: 英文名称:FRAX597
CAS:1286739-19-2
公司名称: BOC Sciences  
联系电话: 16314854226
产品介绍: 英文名称:FRAX597
CAS:1286739-19-2
纯度:>98% 备注:FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.
公司名称: 上海皓元医药股份有限公司  
联系电话: 86-21-58998985
产品介绍: 英文名称:FRAX597
CAS:1286739-19-2
纯度:>98% 包装信息:1066RMB/2mg 备注:试剂级
公司名称: Shanghai Witofly Chemical Co.,Ltd  
联系电话:
产品介绍: 英文名称:FRAX597
CAS:1286739-19-2
公司名称: 上海石鑫医药科技有限公司  
联系电话: 18621020637
产品介绍: 英文名称:FRAX597
CAS:1286739-19-2
纯度:98 包装信息:1g/;5g/
最新发布供应信息
I型P21激活激酶(PAK)抑制剂(FRAX597)_上海泽叶生物科技有限公司
2022/7/1 17:03:44
FRAX597_台州市科瑞生物技术有限公司
2021/6/15 16:50:34
FRAX597
生物活性体外研究体内研究靶点 MSDS 用途与合成方法 FRAX597价格(试剂级) 上下游产品信息
中文名称:FRAX597
中文同义词:I型P21激活激酶(PAK)抑制剂(FRAX597);6-(2-氯-4-(噻唑-5-基)苯基)-8-乙基-2-((4-(4-甲基哌嗪-1-基)苯基)氨基)吡啶并[2,3-D]嘧啶-7(8H)-酮;化合物FRAX597
英文名称:6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one
英文同义词:6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one;FRAX597;Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-;6-(2-chloro-4-(thiazol-5-yl)phenyl)-8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one;6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one;FRAX597, >=98%;6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one USP/EP/BP;6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one
CAS号:1286739-19-2
分子式:C29H28ClN7OS
分子量:558.1
EINECS号:
相关类别:小分子抑制剂,天然产物;抑制剂;细胞生物学试剂;Inhibitors;API
Mol文件:1286739-19-2.mol
FRAX597
FRAX597 性质
熔点 >220°C (dec.)
储存条件 Refrigerator
溶解度 DMSO (Slightly)
形态Solid
颜色Yellow
FRAX597 用途与合成方法
生物活性FRAX597是一种有效的,ATP竞争性的第一类PAKs抑制剂,对PAK1,PAK2,和 PAK3 的 IC50 分别为 8 nM,13 nM,和 19 nM。
体外研究FRAX597 (100 n M) displays a significant inhibitory capacity toward YES1 (87%), RET (82%), CSF1R (91%), TEK (87%), PAK1 (82%), and PAK2 (93%), while displays minimal inhibitory activity towards the group II PAKs: PAK4 (0%), PAK6 (23%), and PAK7 (8%). FRAX597 treatment dramatically impairs the proliferation of Nf2-null SC4 Schwann cells (SC4 cells). FRAX597 displays an IC50 value of 48 nM against wild type PAK1, while IC 50 values against the V342F and V342Y PAK1 mutants are higher than 3μM and 2 μM, respectively. FRAX597 inhibits the proliferation and motility of both benign (Ben-Men1, 3μM) and malignant (KT21-MG1, 0.4 μM) meningiomas cells after treating of 72 h.
体内研究In NOD/SCID mice which bearing Nf2-/-SC4 Schwann cells, FRAX597 (100 mg/kg/day, p.o.) causes more significant tumor growth inhibition cpmpared with control mice. In SCID mice with orthotopic meningioma, FRAX597 (90 mg/kg/day, p.o.) significantly suppresses tumor growth. In KrasG12D mice, treatment with FRAX597 (90 mg/kg/day, p.o.) causes tumor regression and loss of Erk and Akt activity.
靶点

PAK1

8 nM (IC 50 )

PAK2

13 nM (IC 50 )

PAK3

19 nM (IC 50 )

安全信息
FRAX597 价格(试剂级)
更新日期产品编号产品名称CAS编号包装价格
2022/07/01HY-15542AFRAX5971286739-19-22mg500元
2022/07/01HY-15542AFRAX5971286739-19-25mg1000元
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