化合物 T21557
| 中文名称 | 化合物 T21557 |
|---|---|
| 中文同义词 | 钙离子/钙调蛋白依赖激酶II(CAMKII)抑制剂(KN-93 HYDROCHLORIDE);化合物 T21557 |
| 英文名称 | KN93 hydrochloride |
| 英文同义词 | KN 93 hydrochloride;KN-93 (hydrochloride);KN93 hydrochloride;KN-93 HCl;CS-1449;KN93 (HCI);KN-93 (HCI);KN-93 HCI |
| CAS号 | 1956426-56-4 |
| 分子式 | C26H30Cl2N2O4S |
| 分子量 | 537.5 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1956426-56-4.mol |
| 结构式 |  |
化合物 T21557 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMF:10.0(最大浓度 mg/mL);18.6(最大浓度 mM) DMSO:20.5(最大浓度 mg/mL);38.14(最大浓度 mM) 水:0.45(最大浓度 mg/mL);0.84(最大浓度 mM) |
| 形态 | 结晶固体 |
Ki: 370 nM (CaMK-II)
After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-15465A | KN-93 hydrochloride | 1956426-56-4 | 1mg | 558元 |
| 2024/01/25 | HY-15465A | KN-93 hydrochloride | 1956426-56-4 | 5mg | 1100元 |