重复
| 中文名称 | 重复 |
|---|---|
| 中文同义词 | 重复;化合物WS3;N-(6-(4-(3-(4-((4-甲基哌嗪-1-基)甲基)-3-(三氟甲基)苯基)脲基)苯氧基)嘧啶-4-基)环丙烷甲酰胺;N-[6-[4-[[[[4-[(4-甲基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]氨基]羰基]氨基]苯氧基]-4-嘧啶基]环丙烷甲酰胺;N-(6-(4-(3-(4-((4-甲基哌嗪-1-基)甲基)-3-(三氟甲基)苯基)脲基)苯氧基)嘧啶-4-基)环丙烷甲酰胺/N-[6-[4-[[[[4-[(4-甲基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]氨基]羰基]氨基]苯氧基]-4-嘧啶基]环丙烷甲酰胺;化合物WS3,10 MM DMSO 溶液 |
| 英文名称 | WS3 |
| 英文同义词 | N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide;N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide WS3;WS3 N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE;WS3, 1421227-52-2;WS3, >=98%;N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE;WS-3; WS 3;CS-1800 |
| CAS号 | 1421227-52-2 |
| 分子式 | C28H30F3N7O3 |
| 分子量 | 569.58 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂，天然产物;小分子抑制剂;Inhibitors;api |
| Mol文件 | 1421227-52-2.mol |
| 结构式 |  |
重复 性质
| 沸点 | 632.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.423±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | DMSO：可溶10mg/mL，澄清 |
| 酸度系数(pKa) | 11.82±0.20(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
WS3 是一种的增殖分子，可促进鼠和人原代胰岛的胰腺 β 细胞增殖 (β cell proliferation)。WS3 可用于 I 型糖尿病的研究。
IC50: 0.28 μM (β cell proliferation)
WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC 50 value of 0.28 μM.WS3 (1.0 nM-1.0 µM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments.
安全信息
| WGK Germany | 3 |
|---|