艾普拉唑钠
| 中文名称 | 艾普拉唑钠 |
|---|---|
| 中文同义词 | 艾普拉唑钠;1H-苯并咪唑,2-[[((4-甲氧基-3-甲基-2-吡啶基)甲基]亚磺酰基]-6-(1H-吡咯-1-基)-,钠盐(1:1) |
| 英文名称 | Ilaprazole sodium |
| 英文同义词 | Ilaprazole sodium;IY-81149 sodium;Ilaprazole sodium USP/EP/BP;Sodium ilaprazole;oral,Ilaprazole,acid,ulcers,IY 81149,inhibit,IY-81149,TOPK,gastric,Inhibitor,cancer,Ilaprazole sodium,IY81149,pump,Proton Pump;Ilaprazole Sodium Salt |
| CAS号 | 172152-50-0 |
| 分子式 | C19H19N4NaO2S |
| 分子量 | 390.44 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;原料药;Inhibitors |
| Mol文件 | 172152-50-0.mol |
| 结构式 |  |
艾普拉唑钠 性质
| 储存条件 | 4°C, protect from light |
|---|---|
| CAS 数据库 | 172152-50-0 |
| Target | Value |
|
Proton pump
() | |
|
H(+)/K(+)-ATPase
(in rabbit parietal cell preparation) | 6 μM |
On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC 50 of Ilaprazole (IY-81149) sodium is 9 nM.
Ilaprazole sodium (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion.
In anesthetized rats, Ilaprazole sodium dose-dependently increases gastric pH which is lowered by histamine infusion. In the case of i.v. injection, the ED
50
of Ilaprazole sodium and Omeprazole is 1.2 and 1.4 mg/kg and in the case of i.d. administration, the ED
50
of Ilaprazole sodium and omeprazole is 3.9 and 4.1 mg/kg, respectively. Ilaprazole sodium also significantly inhibits pentagastrin-stimulated gastric secretion. Its ED
50
is 2.1 mg/kg and that of Omeprazole was 3.5 mg/kg with i.d. administration. In the case of i.v. injection, Ilaprazole sodium is equipotent to Omeprazole. Ilaprazole sodium also inhibits gastric acid secretion strongly in fistular rats. The ED
50
of Ilaprazole sodium administered intraduodenally is 0.43 mg/kg and that of omeprazole Is 0.68 mg/kg.
| Animal Model: | Male SD rat (after pylorus ligation) |
| Dosage: | 3, 10, 30 mg/kg |
| Administration: | Intraduodenally |
| Result: | The acid output and volume significantly inhibited by about 60 % and 46 % at 3 mg/kg were s, respectively. At 30 mg/kg, it showed 93 % and 73 % inhibition on acid output and volume, respectively. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B2145 | Ilaprazole sodium | 1 mg | 335元 | |
| 2024/01/25 | HY-B2145 | 艾普拉唑钠 Ilaprazole sodium | 172152-50-0 | 5mg | 710元 |