苦参醇
中文名称 | 苦参醇 |
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中文同义词 | |
英文名称 | Kurarinol |
英文同义词 | (2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one;4'',5''-Dihydro-5''-hydroxysophoraflavanone G 5-methyl ether;2-(2,4-dihydroxy-phenyl)-7-hydroxy-8-[2-(3-hydroxy-3-methyl-butyl)-3-methyl-but-3-enyl]-5-methoxy-chroman-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2S)-;KurarinolQ: What is Kurarinol Q: What is the CAS Number of Kurarinol |
CAS号 | 855746-98-4 |
分子式 | C26H32O7 |
分子量 | 456.53 |
EINECS号 | |
相关类别 | 中药对照品;对照品;标准品 -中药标准品;标准品 |
Mol文件 | 855746-98-4.mol |
结构式 |
苦参醇 性质
熔点 | 166-169 °C |
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沸点 | 683.8±55.0 °C(Predicted) |
密度 | 1.250±0.06 g/cm3(Predicted) |
溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
形态 | 粉末 |
酸度系数(pKa) | 7.54±0.40(Predicted) |
IC50: 0.1 μM (mushroom tyrosinase)
Kurarinol manifests relatively low cytotoxic activity (EC
50
>30 μM).
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism.
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3).
Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats.
Animal Model: | Male Sprague-Dawley rats (120-130g), hypercholesterolemic models |
Dosage: | 20 mg/kg |
Administration: | Oral administration, daily, for 3 days |
Result: | Decreased serum TC, TG, and LDL-C levels. |