AM2394
| 中文名称 | AM2394 |
|---|---|
| 中文同义词 | 化合物AM2394;AM-2394游离态;1-(6'-(2-羟基-2-甲基丙氧基)-4-((5-甲基吡啶-3-基)氧基)-[3,3'-联吡啶]-6-基)-3-甲基脲;AM 2394,葡萄糖激酶激活剂;1-(6'-(2-羟基-2-甲基丙氧基)-4-((5-甲基吡啶-3-基)氧基)-[3,3'-联吡啶]-6-基)-3-甲基脲 |
| 英文名称 | AM2394 |
| 英文同义词 | AM2394;1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea;AM2394;AM 2394;CS-2242;N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea;Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-;AM-2394,Hexokinase D,Inhibitor,AM 2394,Glucokinase,inhibit,Hexokinase IV;1-(6'-(2-Hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea |
| CAS号 | 1442684-77-6 |
| 分子式 | C22H25N5O4 |
| 分子量 | 423.46 |
| EINECS号 | |
| 相关类别 | 抑制剂;API |
| Mol文件 | 1442684-77-6.mol |
| 结构式 |  |
AM2394 性质
| 沸点 | 588.8±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.266±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | DMF：1mg/mL； DMSO：1mg/mL； DMSO:PBS (pH 7.2) (1:1)：0.50 mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 12.66±0.70(Predicted) |
AM 2394是一种结构独特的葡萄糖激酶激活剂(GKA)。AM-2394通过一个60 nM的EC50激活GK。AM-2394 是一种新型的 glucokinase 激活剂 (GKA)。AM-2394激活葡萄糖激酶 (GK)，EC50 为 60 nM。
EC50: 60 nM (glucokinase)
AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100221 | AM2394 AM-2394 | 1442684-77-6 | 5mg | 900元 |
| 2024/01/25 | HY-100221 | AM-2394 | 10 mM * 1 mLin DMSO | 990元 |