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| | L-Leucyl-L-Leucine methyl ester (hydrochloride) Basic information |
| Product Name: | L-Leucyl-L-Leucine methyl ester (hydrochloride) | | Synonyms: | L-Leucyl-L-Leucine methyl ester (hydrochloride);methyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloride;Leu-Leu-ome hydrochloride;H-Leu-leu-OMe hydrochloride;L-Leucine, L-leucyl-, methyl ester, monohydrochloride;L-Leucyl-L-Leucine methyl ester;lymphocytes,leukocytes,monocytes,pathway,LLeucylLLeucine methyl ester hydrochloride,LLOMe,inhibit,polymorphonuclear,stress,Leu-Leu methyl ester,cytotoxic,Inhibitor,L Leucyl L Leucine methyl ester hydrochloride,Endogenous Metabolite,endolysosomal | | CAS: | 6491-83-4 | | MF: | C13H27ClN2O3 | | MW: | 294.81808 | | EINECS: | | | Product Categories: | | | Mol File: | 6491-83-4.mol |  |
| | L-Leucyl-L-Leucine methyl ester (hydrochloride) Chemical Properties |
| Melting point | 177-181°C | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| | L-Leucyl-L-Leucine methyl ester (hydrochloride) Usage And Synthesis |
| Description | L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells. | | Uses | H-Leu-leu-OMe HCl |
| | L-Leucyl-L-Leucine methyl ester (hydrochloride) Preparation Products And Raw materials |
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