1599432-18-4
中文名称 | 1599432-18-4 |
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中文同义词 | 依鲁替尼生物素;BTK抑制剂(IBRUTINIB-BIOTIN);N1-(4-((4-(R)-3-(4-氨基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-D]嘧啶-1-基)哌啶) -1-基)-4-氧代丁-2-烯-1-基)(甲基)氨基)丁基)-N5-(15-氧代-19-((3AS,4S,6AR)-2-氧代六氢-1H-噻吩并[3,4-D]咪唑-4-基)-4,7,10-三氧杂-14-氮杂十九烷基)戊二酰胺 |
英文名称 | Ibrutinib-biotin |
英文同义词 | Ibrutinib-biotin;Ibrutinib-biotin-1;Reaxys ID: 26833452;Pentanediamide, N1-[4-[[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-4-oxo-2-buten-1-yl]methylamino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-;N1-(4-(((E)-4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-en-1-yl)(methyl)amino)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide |
CAS号 | 1599432-18-4 |
分子式 | C56H80N12O9S |
分子量 | 1097.3744 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 1599432-18-4.mol |
结构式 | ![]() |
1599432-18-4 性质
沸点 | 1288.9±65.0 °C(Predicted) |
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密度 | 1.33±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:50 mg/mL(45.56 mM) |
形态 | 固体 |
酸度系数(pKa) | 13.90±0.40(Predicted) |
颜色 | 白色至米白色 |
IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8-36.3 nM (Src), 0.187-0.198 μM (ITK),5.34-4.87 μM (JAK3)
Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2025/02/08 | HY-100342 | Ibrutinib-biotin | 1599432-18-4 | 1 mg | 2400元 |
2025/02/08 | HY-100342 | 1599432-18-4 Ibrutinib-biotin | 1599432-18-4 | 5mg | 6000元 |