172377-52-5
中文名称 | 172377-52-5 |
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中文同义词 | 雌二醇 3-氨基磺酸;化合物 T11235 |
英文名称 | Motolimod |
英文同义词 | Estradiol 3-sulfamate;BLE 00084;E2MATE;ES-J 995;Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate;Estradiol Sulfamate |
CAS号 | 172377-52-5 |
分子式 | C18H25NO4S |
分子量 | 351.46 |
EINECS号 | |
相关类别 | |
Mol文件 | 172377-52-5.mol |
结构式 |
172377-52-5 性质
熔点 | 202-204 °C(Solv: methanol (67-56-1)) |
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沸点 | 531.1±60.0 °C(Predicted) |
密度 | 1.319±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:62.5 mg/mL(177.83 mM) |
酸度系数(pKa) | 8.88±0.70(Predicted) |
IC50: 251 nM (estrone sulfatase)
Ki: 133 nM (estrone sulfatase)
Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity.
Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/01/25 | HY-U00112 | 172377-52-5 Estradiol 3-sulfamate | 172377-52-5 | 1mg | 2000元 |
2024/01/25 | HY-U00112 | 172377-52-5 Estradiol 3-sulfamate | 172377-52-5 | 10mM * 1mLin DMSO | 3093元 |