1873376-49-8
| 中文名称 | 1873376-49-8 |
|---|---|
| 中文同义词 | 化合物 T10905;化合物CXCR2-IN-1;化合物CXCR2-IN-1,10 MM DMSO 溶液;1-(4-氯-2-羟基-3-((1-甲基哌啶-4-基)磺酰基)苯基)-3-(2-氯-3-氟苯基)脲 |
| 英文名称 | CXCR2-IN-1 |
| 英文同义词 | CXCR2-IN-1;CXCR2 inhibitor 1;Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-;N-(2-Chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea;CXCR-2-IN-1,CXCR2 IN 1,CXCR2IN1;CXCR2-IN-1, 10 mM in DMSO |
| CAS号 | 1873376-49-8 |
| 分子式 | C19H20Cl2FN3O4S |
| 分子量 | 476.35 |
| EINECS号 | |
| 相关类别 | 标准品 |
| Mol文件 | 1873376-49-8.mol |
| 结构式 |  |
1873376-49-8 性质
| 沸点 | 538.1±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.528±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：5.4 mg/mL（11.34 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 5.02±0.10(Predicted) |
| 颜色 | 白色至米白色 |
CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂，pIC50值为9.3。
|
CXCR2 9.3 (pIC 50 ) |
CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45).
CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-101022 | CXCR2-IN-1 | 1873376-49-8 | 1 mg | 500元 |
| 2025/12/22 | HY-101022 | 1873376-49-8 CXCR2-IN-1 | 1873376-49-8 | 5mg | 900元 |